| 别名 | Smoothened homolog |
| 基因名称 | Endogenous |
| 蛋白名称 | SMO |
| 推荐应用 | |
| 反应物种 | Smo |
| 存储缓冲液 | WB 1:2000-1:10000;IF 1:200-1:1000;ELISA 1:5000-1:20000;IP 1:50-1:200; |
| Human Gene Link | SMO;SMOH;Smoothened homolog;SMO;Protein Gx |
| Human Swissprot No. | 6608 |
| Mouse Gene ID | Q99835 |
| Mouse Swissprot No. | 319757 |
| Rat Gene ID | 25273 |
| Rat Swissprot No. | P97698 |
| 特异性 | Monoclonal |
| 稀释度 | Unmodified |
| 参考分子量 | 86kD |
| 预测分子量 | WB,IF,IP,ELISA |
| 运输及保存条件 | Protein A |
| 宿主 | 100kD |
| 同种型 | Rabbit |
| 背景介绍 | The protein encoded by this gene is a G protein-coupled receptor that interacts with the patched protein, a receptor for hedgehog proteins. The encoded protein tranduces signals to other proteins after activation by a hedgehog protein/patched protein complex. [provided by RefSeq, Jul 2010], |
| 细胞定位 | Membrane ; Multi-pass membrane protein . Cell projection, cilium . |
| 功能 | Disease:Defects in SMO are involved in basal cell carcinoma (BCC).,Function:G protein-coupled receptor that probably associates with the patched protein (PTCH) to transduce the hedgehog's proteins signal. Binding of sonic hedgehog (SHH) to its receptor patched is thought to prevent normal inhibition by patched of smoothened (SMO).,similarity:Belongs to the G-protein coupled receptor Fz/Smo family.,similarity:Contains 1 FZ (frizzled) domain., |
| 纯化 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Clonality | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 修饰类型 | IgG,Kappa |
| 细胞定位 | Membrane ; Multi-pass membrane protein . Cell projection, cilium . |
| 组织表达 | Brain,Embryonic lung,Synovial membrane, |
| 研究领域 | >>Hedgehog signaling pathway;>>Axon guidance;>>Pathways in cancer;>>Proteoglycans in cancer;>>Basal cell carcinoma |
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