| 别名 | Tyk 2 (Tyr1054/1055) |
| 基因名称 | Tyk2 (Phospho Tyr1054/1055) antibody detects endogenous levels of Tyk2 only when phosphorylated at Tyr1054 or tyr1055,and dually phosphorylated at two sites.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):HEyYR |
| 蛋白名称 | TYK2 |
| 推荐应用 | |
| 反应物种 | Tyk 2 |
| 存储缓冲液 | WB 1:10000-1:50000;IF 1:200-1:1000;ELISA 1:5000-1:20000; |
| Human Gene Link | TYK2;Non-receptor tyrosine-protein kinase TYK2 |
| Human Swissprot No. | 7297 |
| Mouse Gene ID | P29597 |
| 特异性 | Monoclonal |
| 稀释度 | Phospho |
| 参考分子量 | 134kD |
| 预测分子量 | WB,IF,ELISA |
| 运输及保存条件 | Protein A |
| 宿主 | 134kD |
| 同种型 | Rabbit |
| 背景介绍 | tyrosine kinase 2(TYK2) Homo sapiens This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E. [provided by RefSeq, Jul 2008], |
| 细胞定位 | nucleus,cytoplasm,cytosol,cytoskeleton,membrane,extrinsic component of cytoplasmic side of plasma membrane,extracellular exosome, |
| 功能 | Catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,Disease:Defects in TYK2 are the cause of protein-tyrosine kinase 2 deficiency (TYK2 deficiency) [MIM:611521]; also called autosomal recessive hyper-IgE syndrome (HIES) with atypical mycobacteriosis. The syndrome consists of a primary immunodeficiency characterized by recurrent skin abscesses, pneumonia, and highly elevated serum IgE.,Domain:The FERM domain mediates interaction with JAKMIP1.,Function:Probably involved in intracellular signal transduction by being involved in the initiation of type I IFN signaling. Phosphorylates the interferon-alpha/beta receptor alpha chain.,online information:TYK2 mutation db,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.,similarity:Contains 1 FERM domain.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 SH2 domain.,subunit:Interacts with JAKMIP1.,tissue specificity:Observed in all cell lines analyzed. Expressed in a variety of lymphoid and non-lymphoid cell lines., |
| 纯化 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Clonality | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 修饰类型 | IgG,Kappa |
| 细胞定位 | nucleus,cytoplasm,cytosol,cytoskeleton,membrane,extrinsic component of cytoplasmic side of plasma membrane,extracellular exosome, |
| 组织表达 | Observed in all cell lines analyzed. Expressed in a variety of lymphoid and non-lymphoid cell lines. |
| 研究领域 | >>Necroptosis;>>Osteoclast differentiation;>>NOD-like receptor signaling pathway;>>JAK-STAT signaling pathway;>>Th1 and Th2 cell differentiation;>>Th17 cell differentiation;>>Toxoplasmosis;>>Hepatitis C;>>Hepatitis B;>>Measles;>>Influenza A;>>Human papillomavirus infection;>>Kaposi sarcoma-associated herpesvirus infection;>>Herpes simplex virus 1 infection;>>Epstein-Barr virus infection;>>Coronavirus disease - COVID-19 |
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