| 别名 | T-cell-specific surface glycoprotein CD28 |
| 基因名称 | Endogenous |
| 蛋白名称 | CD28 |
| 推荐应用 | |
| 反应物种 | CD28 |
| 存储缓冲液 | IHC 1:200-1:1000;WB 1:2000-1:10000;IF 1:200-1:1000;ELISA 1:5000-1:20000;IP 1:50-1:200; |
| Human Gene Link | CD28;T-cell-specific surface glycoprotein CD28;TP44;CD28 |
| Human Swissprot No. | 940 |
| Mouse Gene ID | P10747 |
| Mouse Swissprot No. | 12487 |
| 特异性 | Monoclonal |
| 稀释度 | Unmodified |
| 参考分子量 | 25kD |
| 预测分子量 | WB,IHC,IF,IP,ELISA |
| 运输及保存条件 | Protein A |
| 宿主 | 50kD |
| 同种型 | Rabbit |
| 背景介绍 | The protein encoded by this gene is essential for T-cell proliferation and survival, cytokine production, and T-helper type-2 development. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2011], |
| 细胞定位 | Membrane; Single-pass type I membrane protein.; [Isoform 3]: Cell surface . |
| 功能 | Function:Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival.,online information:CD28 entry,similarity:Contains 1 Ig-like V-type (immunoglobulin-like) domain.,subunit:Homodimer; disulfide-linked. Interacts with DUSP14. Binds to CD80/B7-1 and CD86/B7-2/B70.,tissue specificity:Expressed in T-cells and plasma cells, but not in less mature B-cells., |
| 纯化 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Clonality | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 修饰类型 | IgG,Kappa |
| 细胞定位 | Membrane; Single-pass type I membrane protein.; [Isoform 3]: Cell surface . |
| 组织表达 | Expressed in T-cells and plasma cells, but not in less mature B-cells. |
| 研究领域 | >>Cell adhesion molecules;>>T cell receptor signaling pathway;>>Intestinal immune network for IgA production;>>Type I diabetes mellitus;>>Measles;>>PD-L1 expression and PD-1 checkpoint pathway in cancer;>>Autoimmune thyroid disease;>>Systemic lupus erythematosus;>>Rheumatoid arthritis;>>Allograft rejection;>>Graft-versus-host disease;>>Viral myocarditis |
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