| 别名 | CD27 antigen (CD27L receptor) (T-cell activation antigen CD27) (T14) (Tumor necrosis factor receptor superfamily member 7) (CD antigen CD27) |
| 基因名称 | Endogenous |
| 蛋白名称 | CD27 TNFRSF7 |
| 推荐应用 | |
| 反应物种 | CD27 |
| 存储缓冲液 | IHC 1:200-1:1000;WB 1:10000-1:50000;IF 1:200-1:1000;ELISA 1:5000-1:20000; |
| Human Swissprot No. | 939 |
| Mouse Gene ID | P26842 |
| Mouse Swissprot No. | 21940 |
| 特异性 | Monoclonal |
| 稀释度 | Unmodified |
| 参考分子量 | 29kD |
| 预测分子量 | WB,IHC,IF,ELISA |
| 运输及保存条件 | Protein A |
| 宿主 | 55kD |
| 同种型 | Rabbit |
| 背景介绍 | The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. This receptor transduces signals that lead to the activation of NF-kappaB and MAPK8/JNK. Adaptor proteins TRAF2 and TRAF5 have been shown to mediate the signaling process of this receptor. CD27-binding protein (SIVA), a proapoptotic protein, can bind to this receptor and is thought to play an important role in the apoptosis induced by this receptor. [provided by RefSeq, Jul 2008], |
| 细胞定位 | Membrane; Single-pass type I membrane protein. |
| 功能 | Function:Receptor for CD70/CD27L. May play a role in survival of activated T-cells. May play a role in apoptosis through association with SIVA1.,PTM:Phosphorylated and O-glycosylated.,similarity:Contains 3 TNFR-Cys repeats.,subunit:Homodimer. Interacts with SIVA1 and TRAF2.,tissue specificity:Found in most T-lymphocytes., |
| 纯化 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Clonality | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 修饰类型 | IgG,Kappa |
| 细胞定位 | Membrane; Single-pass type I membrane protein. |
| 组织表达 | Found in most T-lymphocytes. |
| 研究领域 | >>Cytokine-cytokine receptor interaction |
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