| 别名 | Radixin |
| 基因名称 | Endogenous |
| 蛋白名称 | RDX |
| 推荐应用 | |
| 反应物种 | Radixin |
| 存储缓冲液 | IHC 1:200-1:1000;WB 1:2000-1:10000;IF 1:200-1:1000;ELISA 1:5000-1:20000;IP 1:50-1:200; |
| Human Gene Link | RDX;Radixin |
| Human Swissprot No. | 5962 |
| Mouse Gene ID | P35241 |
| Mouse Swissprot No. | 19684 |
| 特异性 | Monoclonal |
| 稀释度 | Unmodified |
| 参考分子量 | 69kD |
| 预测分子量 | WB,IHC,IF,IP,ELISA |
| 运输及保存条件 | Protein A |
| 宿主 | 80kD |
| 同种型 | Rabbit |
| 背景介绍 | Radixin is a cytoskeletal protein that may be important in linking actin to the plasma membrane. It is highly similar in sequence to both ezrin and moesin. The radixin gene has been localized by fluorescence in situ hybridization to 11q23. A truncated version representing a pseudogene (RDXP2) was assigned to Xp21.3. Another pseudogene that seemed to lack introns (RDXP1) was mapped to 11p by Southern and PCR analyses. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012], |
| 细胞定位 | Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cleavage furrow. Cell projection, microvillus . Highly concentrated in the undercoat of the cell-to-cell adherens junction and the cleavage furrow in the interphase and mitotic phase, respectively. |
| 功能 | Disease:Defects in RDX are the cause of non-syndromic sensorineural deafness autosomal recessive type 24 (DFNB24) [MIM:611022]. DFNB24 is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.,Domain:The N-terminal domain interacts with the C-terminal domain of LAYN. An interdomain interaction between its N-terminal and C-terminal domains inhibits its ablilty to bind LAYN. In the presence of acidic phospholipids, the interdomain interaction is inhibited and this enhances binding to LAYN.,Function:Probably plays a crucial role in the binding of the barbed end of actin filaments to the plasma membrane.,PTM:Phosphorylated by tyrosine-protein kinases.,similarity:Contains 1 FERM domain.,subcellular location:Highly concentrated in the undercoat of the cell-to-cell adherens junction and the cleavage furrow in the interphase and mitotic phase, respectively.,subunit:Binds SLC9A3R1. Interacts with NHERF1, NHERF2, LAYN, MME/NEP and ICAM2., |
| 纯化 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Clonality | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 修饰类型 | IgG,Kappa |
| 细胞定位 | Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cleavage furrow. Cell projection, microvillus . Highly concentrated in the undercoat of the cell-to-cell adherens junction and the cleavage furrow in the interphase and mitotic phase, respectively. |
| 组织表达 | Brain,Hippocampus,Liver,Lung,Testis,Uterus, |
| 研究领域 | >>Tight junction;>>Regulation of actin cytoskeleton;>>Proteoglycans in cancer;>>MicroRNAs in cancer |
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