| 别名 | 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase) (EC 1.1.1.34) |
| 基因名称 | Endogenous |
| 蛋白名称 | HMGCR |
| 推荐应用 | |
| 反应物种 | HMGCR |
| 存储缓冲液 | IHC 1:100-1:500;WB 1:2000-1:10000;IF 1:200-1:1000;ELISA 1:5000-1:20000;IP 1:50-1:200; |
| Human Swissprot No. | 3156 |
| Mouse Gene ID | P04035 |
| Mouse Swissprot No. | 15357 |
| Rat Gene ID | 25675 |
| Rat Swissprot No. | P51639 |
| 特异性 | Monoclonal |
| 稀释度 | Unmodified |
| 参考分子量 | 98kD |
| 预测分子量 | WB,IHC,IF,IP,ELISA |
| 运输及保存条件 | Protein A |
| 宿主 | 98kD |
| 同种型 | Rabbit |
| 细胞定位 | Endoplasmic reticulum membrane ; Multi-pass membrane protein . Peroxisome membrane ; Multi-pass membrane protein . |
| 功能 | Catalyzes the conversion of (3S)-hydroxy-3-methylglutaryl-CoA (HMG-CoA) to mevalonic acid, the rate-limiting step in the synthesis of cholesterol and other isoprenoids, thus plays a critical role in cellular cholesterol homeostasis . HMGCR is the main target of statins, a class of cholesterol-lowering drugs . |
| 纯化 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Clonality | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 修饰类型 | IgG,Kappa |
| 细胞定位 | Endoplasmic reticulum membrane ; Multi-pass membrane protein . Peroxisome membrane ; Multi-pass membrane protein . |
| 组织表达 | [Isoform 1]: Ubiquitously expressed with the highest levels in the cerebellum, fetal brain, testis, skin and adrenal gland. ; [Isoform 2]: Detected in the cerebellum, fetal brain, testis and adrenal gland. ; [Isoform 3]: Low abundance except in skin, esophagus, and uterine cervix. |
周一至周日 8:00-18:00
