| 别名 | Glycogen [starch] synthase muscle |
| 基因名称 | Glycogen synthase 1(Phospho Ser641) Antibody detects endogenous levels of Glycogen Synthase 1 protein only when phosphorylated at S641.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):PAsVP |
| 蛋白名称 | GYS1 |
| 推荐应用 | |
| 反应物种 | Glycogen Synthase 1 |
| 存储缓冲液 | IHC 1:200-1:1000;WB 1:2000-1:10000;IF 1:200-1:1000;ELISA 1:5000-1:20000;IP 1:50-1:200; |
| Human Gene Link | GYS1;GYS;Glycogen [starch] synthase;muscle |
| Human Swissprot No. | 2997 |
| Mouse Gene ID | P13807 |
| Mouse Swissprot No. | 14936 |
| Rat Gene ID | 690987 |
| Rat Swissprot No. | A2RRU1 |
| 特异性 | Monoclonal |
| 稀释度 | Phospho |
| 参考分子量 | 84kD |
| 预测分子量 | WB,IHC,IF,IP,ELISA |
| 运输及保存条件 | Protein A |
| 宿主 | 84kD |
| 同种型 | Rabbit |
| 背景介绍 | The protein encoded by this gene catalyzes the addition of glucose monomers to the growing glycogen molecule through the formation of alpha-1,4-glycoside linkages. Mutations in this gene are associated with muscle glycogen storage disease. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009], |
| 细胞定位 | cytosol,membrane,inclusion body, |
| 功能 | Catalytic activity:UDP-glucose ((1->4)-alpha-D-glucosyl)(n) = UDP + ((1->4)-alpha-D-glucosyl)(n+1).,Disease:Defects in GYS1 are the cause of muscle glycogen storage disease type 0 (GSD0b) [MIM:611556]; also called muscle glycogen synthase deficiency. GSD0 is a metabolic disorder characterized by fasting hypoglycemia presenting in infancy or early childhood. The role of muscle glycogen is to provide critical energy during bursts of activity and sustained muscle work.,enzyme regulation:Allosteric activation by glucose-6-phosphate. Phosphorylation reduces the activity towards UDP-glucose. When in the non-phosphorylated state, glycogen synthase does not require glucose-6-phosphate as an allosteric activator; when phosphorylated it does.,Function:Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan.,pathway:Glycan biosynthesis; glycogen biosynthesis.,similarity:Belongs to the glycosyltransferase 3 family., |
| 纯化 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Clonality | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 修饰类型 | IgG,Kappa |
| 细胞定位 | cytosol,membrane,inclusion body, |
| 组织表达 | Endometrium,Heart,Kidney,Lymph,Muscle,Skin, |
| 研究领域 | >>Starch and sucrose metabolism;>>Metabolic pathways;>>PI3K-Akt signaling pathway;>>AMPK signaling pathway;>>Insulin signaling pathway;>>Glucagon signaling pathway;>>Insulin resistance;>>Diabetic cardiomyopathy |
周一至周日 8:00-18:00
