| 别名 | D(1A) dopamine receptor |
| 基因名称 | Endogenous |
| 蛋白名称 | DRD1 |
| 推荐应用 | |
| 反应物种 | DRD1 |
| 存储缓冲液 | IHC 1:400-1:1000;WB 1:500-1:2000;IF 1:200-1:1000;ELISA 1:5000-1:20000; |
| Human Gene Link | DRD1;D;1A;dopamine receptor;Dopamine D1 receptor |
| Human Swissprot No. | 1812 |
| Mouse Gene ID | P21728 |
| Mouse Swissprot No. | 13488 |
| Rat Gene ID | 24316 |
| Rat Swissprot No. | P18901 |
| 特异性 | Monoclonal |
| 稀释度 | Unmodified |
| 参考分子量 | 49kD |
| 预测分子量 | WB,IHC,IF,ELISA |
| 运输及保存条件 | Protein A |
| 宿主 | 75kD |
| 同种型 | Rabbit |
| 背景介绍 | This gene encodes the D1 subtype of the dopamine receptor. The D1 subtype is the most abundant dopamine receptor in the central nervous system. This G-protein coupled receptor stimulates adenylyl cyclase and activates cyclic AMP-dependent protein kinases. D1 receptors regulate neuronal growth and development, mediate some behavioral responses, and modulate dopamine receptor D2-mediated events. Alternate transcription initiation sites result in two transcript variants of this gene. [provided by RefSeq, Jul 2008], |
| 细胞定位 | Cell membrane ; Multi-pass membrane protein . Endoplasmic reticulum membrane ; Multi-pass membrane protein . Cell projection, dendrite . Cell projection, dendritic spine . Transport from the endoplasmic reticulum to the cell surface is regulated by interaction with DNAJC14. . |
| 功能 | Function:This is one of the five types (D1 to D5) of receptors for dopamine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.,similarity:Belongs to the G-protein coupled receptor 1 family.,subcellular location:Transport from the endoplasmic reticulum to the cell surface is regulated by interaction with DNAJC14.,subunit:Interacts with DNAJC14 via its C-terminus (By similarity). Interacts with DRD1IP.,tissue specificity:Detected in caudate, nucleus accumbens and in the olfactory tubercle., |
| 纯化 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Clonality | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 修饰类型 | IgG,Kappa |
| 细胞定位 | Cell membrane ; Multi-pass membrane protein . Endoplasmic reticulum membrane ; Multi-pass membrane protein . Cell projection, dendrite . Cell projection, dendritic spine . Transport from the endoplasmic reticulum to the cell surface is regulated by interaction with DNAJC14. . |
| 组织表达 | Detected in caudate, nucleus accumbens and in the olfactory tubercle. |
| 研究领域 | >>Calcium signaling pathway;>>cAMP signaling pathway;>>Neuroactive ligand-receptor interaction;>>Gap junction;>>Dopaminergic synapse;>>Parkinson disease;>>Cocaine addiction;>>Amphetamine addiction;>>Morphine addiction;>>Alcoholism |
周一至周日 8:00-18:00
