| 别名 | Protein numb homolog |
| 基因名称 | Endogenous |
| 蛋白名称 | NUMB |
| 推荐应用 | |
| 反应物种 | NUMB |
| 存储缓冲液 | IHC 1:200-1:1000;WB 1:500-1:2000;IF 1:200-1:1000;ELISA 1:5000-1:20000;IP 1:50-1:200; |
| Human Gene Link | NUMB;Protein numb homolog;h-Numb;Protein S171 |
| Human Swissprot No. | 8650 |
| Mouse Gene ID | P49757 |
| Mouse Swissprot No. | 18222 |
| Rat Swissprot No. | Q2LC84 |
| 特异性 | Monoclonal |
| 稀释度 | Unmodified |
| 参考分子量 | 71kD |
| 预测分子量 | WB,IHC,IF,IP,ELISA |
| 运输及保存条件 | Protein A |
| 宿主 | 71kD |
| 同种型 | Rabbit |
| 背景介绍 | The protein encoded by this gene plays a role in the determination of cell fates during development. The encoded protein, whose degradation is induced in a proteasome-dependent manner by MDM2, is a membrane-bound protein that has been shown to associate with EPS15, LNX1, and NOTCH1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016], |
| 细胞定位 | Cell membrane ; Peripheral membrane protein ; Cytoplasmic side . Endosome membrane ; Peripheral membrane protein ; Cytoplasmic side . Localizes to perinuclear endosomes in an AAK1-dependent manner. . |
| 功能 | Function:Implicated in the control of cell fate decisions during development.,PTM:Isoform 1 and isoform 2 are ubiquitinated by LNX leading to their subsequent proteasomal degradation (By similarity). Ubiquitinated; mediated by SIAH1 and leading to its subsequent proteasomal degradation.,sequence Caution:Intron retention.,similarity:Contains 1 PID domain.,subunit:Interacts with EPS15, LNX and NOTCH1. May interact with DUOXA1. Interacts with RALBP1 in a complex also containing EPN1 and TFAP2A during interphase and mitosis., |
| 纯化 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Clonality | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 修饰类型 | IgG,Kappa |
| 细胞定位 | Cell membrane ; Peripheral membrane protein ; Cytoplasmic side . Endosome membrane ; Peripheral membrane protein ; Cytoplasmic side . Localizes to perinuclear endosomes in an AAK1-dependent manner. . |
| 组织表达 | B cells,Blood,Brain,Cervix carcinoma,Epithelium,Fetal brain,HeLa cells,Live |
| 研究领域 | >>Notch signaling pathway |
周一至周日 8:00-18:00
