| 别名 | Histone acetyltransferase KAT2A |
| 基因名称 | Endogenous |
| 蛋白名称 | KAT2A |
| 推荐应用 | |
| 反应物种 | GCN5 |
| 存储缓冲液 | WB 1:2000-1:10000;IF 1:200-1:1000;ELISA 1:5000-1:20000;IP 1:50-1:200; |
| Human Gene Link | KAT2A;GCN5;GCN5L2;HGCN5;Histone acetyltransferase KAT2A;General control of amino acid synthesis protein 5-like 2;Histone acetyltransferase GCN5;HsGCN5;Lysine acetyltransferase 2A;STAF97 |
| Human Swissprot No. | 2648 |
| Mouse Gene ID | Q92830 |
| Mouse Swissprot No. | 14534 |
| 特异性 | Monoclonal |
| 稀释度 | Unmodified |
| 参考分子量 | 94kD |
| 预测分子量 | WB,IF,IP,ELISA |
| 运输及保存条件 | Protein A |
| 宿主 | 94kD |
| 同种型 | Rabbit |
| 背景介绍 | KAT2A, or GCN5, is a histone acetyltransferase (HAT) that functions primarily as a transcriptional activator. It also functions as a repressor of NF-kappa-B (see MIM 164011) by promoting ubiquitination of the NF-kappa-B subunit RELA (MIM 164014) in a HAT-independent manner (Mao et al., 2009 [PubMed 19339690]).[supplied by OMIM, Sep 2009], |
| 细胞定位 | Nucleus . Chromosome . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Mainly localizes to the nucleus (PubMed:27796307). Also localizes to centrosomes in late G1 and around the G1/S transition, coinciding with the onset of centriole formation (PubMed:27796307). . |
| 功能 | somitogenesis, regionalization, chromatin organization, chromatin remodeling, transcription, transcription, DNA-dependent, regulation of transcription, DNA-dependent, regulation of transcription from RNA polymerase II promoter,transcription from RNA polymerase II promoter, protein amino acid acetylation, pattern specification process,embryonic development ending in birth or egg hatching, anterior/posterior pattern formation, chromatin modification,covalent chromatin modification, histone modification, histone acetylation, histone deubiquitination, protein deubiquitination, RNA biosynthetic process, segmentation, chordate embryonic development, protein amino acid acylation, histone H3 acetylation, regulation of transcription, regulation of RNA metabolic process, chromosome organization, protein modification by small protein removal, protein modification by small protein conjugation or removal, |
| 纯化 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Clonality | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 修饰类型 | IgG,Kappa |
| 细胞定位 | Nucleus . Chromosome . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Mainly localizes to the nucleus (PubMed:27796307). Also localizes to centrosomes in late G1 and around the G1/S transition, coinciding with the onset of centriole formation (PubMed:27796307). . |
| 组织表达 | Expressed in all tissues tested. |
| 研究领域 | >>Viral life cycle - HIV-1;>>Notch signaling pathway;>>Thyroid hormone signaling pathway;>>Human T-cell leukemia virus 1 infection;>>Viral carcinogenesis |
周一至周日 8:00-18:00
