| 别名 | Dihydropyrimidinase-related protein 2 |
| 基因名称 | Endogenous |
| 蛋白名称 | DPYSL2 |
| 推荐应用 | |
| 反应物种 | CRMP-2 |
| 存储缓冲液 | IHC 1:200-1:1000;WB 1:2000-1:10000;IF 1:200-1:1000;ELISA 1:5000-1:20000;IP 1:50-1:200; |
| Human Gene Link | DPYSL2;CRMP2;ULIP2;Dihydropyrimidinase-related protein 2;DRP-2;Collapsin response mediator protein 2;CRMP-2;N2A3;Unc-33-like phosphoprotein 2;ULIP-2 |
| Human Swissprot No. | 1808 |
| Mouse Gene ID | Q16555 |
| Mouse Swissprot No. | 12934 |
| Rat Gene ID | 25416 |
| Rat Swissprot No. | P47942 |
| 特异性 | Monoclonal |
| 稀释度 | Unmodified |
| 参考分子量 | 62kD |
| 预测分子量 | WB,IHC,IF,IP,ELISA |
| 运输及保存条件 | Protein A |
| 宿主 | 62kD |
| 同种型 | Rabbit |
| 背景介绍 | This gene encodes a member of the collapsin response mediator protein family. Collapsin response mediator proteins form homo- and hetero-tetramers and facilitate neuron guidance, growth and polarity. The encoded protein promotes microtubule assembly and is required for Sema3A-mediated growth cone collapse, and also plays a role in synaptic signaling through interactions with calcium channels. This gene has been implicated in multiple neurological disorders, and hyperphosphorylation of the encoded protein may play a key role in the development of Alzheimer's disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011], |
| 细胞定位 | Cytoplasm, cytosol . Cytoplasm, cytoskeleton . Membrane . Tightly but non-covalently associated with membranes. |
| 功能 | Function:Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration.,PTM:3F4, a monoclonal antibody which strongly stains neurofibrillary tangles in Alzheimer disease brains, specifically labels DPYSL2 when phosphorylated on Ser-518, Ser-522 and Thr-509.,similarity:Belongs to the DHOase family. Hydantoinase/dihydropyrimidinase subfamily.,subunit:Homotetramer, and heterotetramer with CRMP1, DPYSL3, DPYSL4 or DPYSL5 (By similarity). Interacts through its C-terminus with the C-terminus of CYFIP1/SRA1. Interacts with HTR4.,tissue specificity:Ubiquitous., |
| 纯化 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Clonality | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 修饰类型 | IgG,Kappa |
| 细胞定位 | Cytoplasm, cytosol . Cytoplasm, cytoskeleton . Membrane . Tightly but non-covalently associated with membranes. |
| 组织表达 | Ubiquitous. |
| 研究领域 | >>Axon guidance |
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