| 别名 | G6PD(Glucose 6 Phosphate Dehydrogenase) |
| 基因名称 | Endogenous |
| 蛋白名称 | G6PD |
| 推荐应用 | |
| 反应物种 | G6PD |
| 存储缓冲液 | IHC 1:200-1:1000;WB 1:2000-1:10000;IF 1:200-1:1000;ELISA 1:5000-1:20000;IP 1:50-1:200; |
| Human Gene Link | G6PD;Glucose-6-phosphate 1-dehydrogenase;G6PD |
| Human Swissprot No. | 2539 |
| Mouse Gene ID | P11413 |
| Rat Swissprot No. | P05370 |
| 特异性 | Monoclonal |
| 稀释度 | Unmodified |
| 参考分子量 | 59kD |
| 预测分子量 | WB,IHC,IF,IP,ELISA |
| 运输及保存条件 | Protein A |
| 宿主 | 59kD |
| 同种型 | Rabbit |
| 背景介绍 | glucose-6-phosphate dehydrogenase(G6PD) Homo sapiens This gene encodes glucose-6-phosphate dehydrogenase. This protein is a cytosolic enzyme encoded by a housekeeping X-linked gene whose main function is to produce NADPH, a key electron donor in the defense against oxidizing agents and in reductive biosynthetic reactions. G6PD is remarkable for its genetic diversity. Many variants of G6PD, mostly produced from missense mutations, have been described with wide ranging levels of enzyme activity and associated clinical symptoms. G6PD deficiency may cause neonatal jaundice, acute hemolysis, or severe chronic non-spherocytic hemolytic anemia. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008], |
| 细胞定位 | Cytoplasm, cytosol . Membrane; Peripheral membrane protein . |
| 功能 | Catalytic activity:D-glucose 6-phosphate + NADP(+) = D-glucono-1,5-lactone 6-phosphate + NADPH.,Disease:Defects in G6PD are the cause of chronic non-spherocytic hemolytic anemia (CNSHA) [MIM:305900]. Deficiency of G6PD is associated with hemolytic anemia in two different situations. First, in areas in which malaria has been endemic, G6PD-deficiency alleles have reached high frequencies (1% to 50%) and deficient individuals, though essentially asymptomatic in the steady state, have a high risk of acute hemolytic attacks. Secondly, sporadic cases of G6PD deficiency occur at a very low frequencies, and they usually present a more severe phenotype. Several types of CNSHA are recognized. Class-I variants are associated with severe NSHA; class-II have an activity <10% of normal; class-III have an activity of 10% to 60% of normal; class-IV have near normal activity.,Function:Produces pentose sugars for nucleic acid synthesis and main producer of NADPH reducing power.,miscellaneous:Has NADP both as cofactor (bound to the N-terminal domain) and as structural element bound to the C-terminal domain.,online information:G6PD deficiency resource,online information:G6PD mutation database,online information:The Singapore human mutation and polymorphism database,pathway:Carbohydrate degradation; pentose phosphate pathway.,pathway:Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3.,polymorphism:The sequence shown is that of variant B, the most common variant.,similarity:Belongs to the glucose-6-phosphate dehydrogenase family.,subunit:Homodimer or homotetramer.,tissue specificity:The long isoform is found in lymphoblasts, granulocytes and sperm., |
| 纯化 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Clonality | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 修饰类型 | IgG,Kappa |
| 细胞定位 | Cytoplasm, cytosol . Membrane; Peripheral membrane protein . |
| 组织表达 | Isoform Long is found in lymphoblasts, granulocytes and sperm. |
| 研究领域 | >>Pentose phosphate pathway;>>Glutathione metabolism;>>Metabolic pathways;>>Carbon metabolism;>>Central carbon metabolism in cancer;>>Diabetic cardiomyopathy |
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