| 别名 | Transcription factor GATA-4 |
| 基因名称 | Endogenous |
| 蛋白名称 | GATA4 |
| 推荐应用 | |
| 反应物种 | GATA-4 |
| 存储缓冲液 | IHC 1:200-1:1000;WB 1:500-1:2000;IF 1:200-1:1000;ELISA 1:5000-1:20000; |
| Human Gene Link | GATA4;Transcription factor GATA-4;GATA-binding factor 4 |
| Human Swissprot No. | 2626 |
| Mouse Gene ID | P43694 |
| Mouse Swissprot No. | 14463 |
| Rat Gene ID | 54254 |
| Rat Swissprot No. | P46152 |
| 特异性 | Monoclonal |
| 稀释度 | Unmodified |
| 参考分子量 | 45kD |
| 预测分子量 | WB,IHC,IF,ELISA |
| 运输及保存条件 | Protein A |
| 宿主 | 55kD |
| 同种型 | Rabbit |
| 背景介绍 | This gene encodes a member of the GATA family of zinc-finger transcription factors. Members of this family recognize the GATA motif which is present in the promoters of many genes. This protein is thought to regulate genes involved in embryogenesis and in myocardial differentiation and function, and is necessary for normal testicular development. Mutations in this gene have been associated with cardiac septal defects. Additionally, alterations in gene expression have been associated with several cancer types. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015], |
| 细胞定位 | Nucleus . |
| 功能 | Disease:Defects in GATA4 are the cause of atrial septal defect type 2 (ASD2) [MIM:607941]. ASD2 is a congenital heart malformation characterized by incomplete closure of the wall between the atria resulting in blood flow from the left to the right atria. ASD2 patients show other heart abnormalities including ventricular and atrioventricular septal defects, pulmonary valve thickening or insufficiency of the cardiac valves. ASD2 is not associated with defects in the cardiac conduction system or non-cardiac abnormalities.,Function:Transcriptional activator. Binds to the consensus sequence 5'-AGATAG-3'. Acts as a transcriptional activator of ANF in cooperation with NKX2-5.,similarity:Contains 2 GATA-type zinc fingers.,subunit:Interacts with ZNF260 (By similarity). Interacts with the homeobox domain of NKX2-5 through its C-terminal zinc finger. Also interacts with JARID2 which represses its ability to activate transcription of ANF. Interacts with NFATC4., |
| 纯化 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Clonality | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 修饰类型 | IgG,Kappa |
| 细胞定位 | Nucleus . |
| 组织表达 | Heart,Lung, |
| 研究领域 | >>cGMP-PKG signaling pathway;>>Cellular senescence;>>Tight junction;>>Thyroid hormone signaling pathway |
周一至周日 8:00-18:00
