| 别名 | Serine/threonine-protein kinase pim-1 |
| 基因名称 | Endogenous |
| 蛋白名称 | PIM1 |
| 推荐应用 | |
| 反应物种 | Pim-1 |
| 存储缓冲液 | IHC 1:200-1:1000;WB 1:2000-1:10000;IF 1:200-1:1000;ELISA 1:5000-1:20000; |
| Human Gene Link | PIM1;Serine/threonine-protein kinase pim-1 |
| Human Swissprot No. | 5292 |
| Mouse Gene ID | P11309 |
| Rat Gene ID | 24649 |
| Rat Swissprot No. | P26794 |
| 特异性 | Monoclonal |
| 稀释度 | Unmodified |
| 参考分子量 | 45kD |
| 预测分子量 | WB,IHC,IF,ELISA |
| 运输及保存条件 | Protein A |
| 宿主 | 34kD |
| 同种型 | Rabbit |
| 背景介绍 | The protein encoded by this gene belongs to the Ser/Thr protein kinase family, and PIM subfamily. This gene is expressed primarily in B-lymphoid and myeloid cell lines, and is overexpressed in hematopoietic malignancies and in prostate cancer. It plays a role in signal transduction in blood cells, contributing to both cell proliferation and survival, and thus provides a selective advantage in tumorigenesis. Both the human and orthologous mouse genes have been reported to encode two isoforms (with preferential cellular localization) resulting from the use of alternative in-frame translation initiation codons, the upstream non-AUG (CUG) and downstream AUG codons (PMIDs:16186805, 1825810).[provided by RefSeq, Aug 2011], |
| 细胞定位 | [Isoform 1]: Cytoplasm. Nucleus.; [Isoform 2]: Cell membrane. |
| 功能 | Catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Manganese.,Function:Plays a role in signal transduction in blood cells. Contributes to both cell proliferation and survival and thus provide a selective advantage in tumorigenesis. May affect the structure or silencing of chromatin by phosphorylating HP1 gamma/CBX3.,induction:Strongly induced in leukocytes by the JAK/STAT pathway in response to cytokines.,PTM:Autophosphorylated on both serine/threonine and tyrosine residues.,similarity:Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily.,similarity:Contains 1 protein kinase domain.,subunit:Binds to RP9. Isoform 2 is isolated as a monomer whereas isoform 1 complexes with other proteins. Isoform 1, but not isoform 2, binds BMX.,tissue specificity:Expressed primarily in cells of the hematopoietic and germline lineages. Isoform 1 and isoform 2 are both expressed in prostate cancer cell lines., |
| 纯化 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Clonality | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 修饰类型 | IgG,Kappa |
| 细胞定位 | [Isoform 1]: Cytoplasm. Nucleus.; [Isoform 2]: Cell membrane. |
| 组织表达 | Expressed primarily in cells of the hematopoietic and germline lineages. Isoform 1 and isoform 2 are both expressed in prostate cancer cell lines. |
| 研究领域 | >>JAK-STAT signaling pathway;>>AGE-RAGE signaling pathway in diabetic complications;>>Pathways in cancer;>>MicroRNAs in cancer;>>Acute myeloid leukemia |
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