| 别名 | Claudin-4 |
| 基因名称 | Endogenous |
| 蛋白名称 | CLDN4 |
| 推荐应用 | |
| 反应物种 | Claudin-4 |
| 存储缓冲液 | IHC 1:100-1:500;WB 1:2000-1:10000;IF 1:200-1:1000;ELISA 1:5000-1:20000;IP 1:50-1:200; |
| Human Gene Link | CLDN4;CPER;CPETR1;WBSCR8;Claudin-4;Clostridium perfringens enterotoxin receptor;CPE-R;CPE-receptor;Williams-Beuren syndrome chromosomal region 8 protein |
| Human Swissprot No. | 1364 |
| Mouse Gene ID | O14493 |
| Mouse Swissprot No. | 12740 |
| 特异性 | Monoclonal |
| 稀释度 | Unmodified |
| 参考分子量 | 22kD |
| 预测分子量 | WB,IHC,IF,IP,ELISA |
| 运输及保存条件 | Protein A |
| 宿主 | 18kD |
| 同种型 | Rabbit |
| 背景介绍 | The protein encoded by this intronless gene belongs to the claudin family. Claudins are integral membrane proteins that are components of the epithelial cell tight junctions, which regulate movement of solutes and ions through the paracellular space. This protein is a high-affinity receptor for Clostridium perfringens enterotoxin (CPE) and may play a role in internal organ development and function during pre- and postnatal life. This gene is deleted in Williams-Beuren syndrome, a neurodevelopmental disorder affecting multiple systems. [provided by RefSeq, Sep 2013], |
| 细胞定位 | Cell junction, tight junction . Cell membrane ; Multi-pass membrane protein . CLDN4 is required for tight junction localization in the kidney. . |
| 功能 | Disease:Haploinsufficiency of CLDN4 may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in Williams-Beuren syndrome (WBS), a rare developmental disorder. It is a contiguous gene deletion syndrome involving genes from chromosome band 7q11.23.,Function:Plays a major role in tight junction-specific obliteration of the intercellular space.,similarity:Belongs to the claudin family.,subunit:Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3., |
| 纯化 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Clonality | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 修饰类型 | IgG,Kappa |
| 细胞定位 | Cell junction, tight junction . Cell membrane ; Multi-pass membrane protein . CLDN4 is required for tight junction localization in the kidney. . |
| 组织表达 | Colon,Fetal brain,Trachea, |
| 研究领域 | >>Cell adhesion molecules;>>Tight junction;>>Leukocyte transendothelial migration;>>Pathogenic Escherichia coli infection;>>Hepatitis C |
周一至周日 8:00-18:00
