| 别名 | 6-phosphofructokinase type C |
| 基因名称 | Endogenous |
| 蛋白名称 | PFKP |
| 推荐应用 | |
| 反应物种 | PFK-C |
| 存储缓冲液 | IHC 1:1000-1:4000;WB 1:2000-1:10000;IF 1:200-1:1000;ELISA 1:5000-1:20000;IP 1:50-1:200; |
| Human Gene Link | PFKP;PFKF;6-phosphofructokinase type C;6-phosphofructokinase;platelet type;Phosphofructo-1-kinase isozyme C;PFK-C;Phosphofructokinase 1;Phosphohexokinase |
| Human Swissprot No. | 5214 |
| Mouse Gene ID | Q01813 |
| Mouse Swissprot No. | 56421 |
| Rat Gene ID | 60416 |
| Rat Swissprot No. | P47860 |
| 特异性 | Monoclonal |
| 稀释度 | Unmodified |
| 参考分子量 | 86kD |
| 预测分子量 | WB,IHC,IF,IP,ELISA |
| 运输及保存条件 | Protein A |
| 宿主 | 80kD |
| 同种型 | Rabbit |
| 背景介绍 | This gene encodes a member of the phosphofructokinase A protein family. The encoded enzyme is the platelet-specific isoform of phosphofructokinase and plays a key role in glycolysis regulation. This gene may play a role in metabolic reprogramming in some cancers, including clear cell renal cell carcinomas, and cancer of the bladder, breast, and lung. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016], |
| 细胞定位 | Cytoplasmic |
| 功能 | Catalytic activity:ATP + D-fructose 6-phosphate = ADP + D-fructose 1,6-bisphosphate.,cofactor:Magnesium.,enzyme regulation:Allosteric enzyme activated by ADP, AMP, or fructose bisphosphate and inhibited by ATP or citrate.,miscellaneous:In human PFK exists as a system of 3 types of subunits, PFKM (muscle), PFKL (liver) and PFKP (platelet) isoenzymes.,pathway:Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.,similarity:Belongs to the phosphofructokinase family. Two domains subfamily.,subunit:Tetramer. Muscle is M4, liver is L4, and red cell is M3L, M2L2, or ML3. A subunit composition with a higher proportion of platelet type subunits is found in platelets, brain and fibroblasts., |
| 纯化 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Clonality | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 修饰类型 | IgG,Kappa |
| 细胞定位 | Cytoplasmic |
| 组织表达 | Brain,Epithelium,Kidney,Pancreatic islet,Placenta,Prostate, |
| 研究领域 | >>Glycolysis / Gluconeogenesis;>>Pentose phosphate pathway;>>Fructose and mannose metabolism;>>Galactose metabolism;>>Metabolic pathways;>>Carbon metabolism;>>Biosynthesis of amino acids;>>RNA degradation;>>HIF-1 signaling pathway;>>AMPK signaling pathway;>>Thyroid hormone signaling pathway;>>Glucagon signaling pathway;>>Central carbon metabolism in cancer |
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