| 别名 | GRB2-associated-binding protein 1 |
| 基因名称 | Endogenous |
| 蛋白名称 | GAB1 |
| 推荐应用 | |
| 反应物种 | Gab 1 |
| 存储缓冲液 | WB 1:2000-1:10000;IF 1:200-1:1000;ELISA 1:5000-1:20000;IP 1:50-1:200; |
| Human Gene Link | GAB1;GRB2-associated-binding protein 1;GRB2-associated binder 1;Growth factor receptor bound protein 2-associated protein 1 |
| Human Swissprot No. | 2549 |
| Mouse Gene ID | Q13480 |
| Mouse Swissprot No. | 14388 |
| 特异性 | Monoclonal |
| 稀释度 | Unmodified |
| 参考分子量 | 77kD |
| 预测分子量 | WB,IF,IP,ELISA |
| 运输及保存条件 | Protein A |
| 宿主 | 110kD |
| 同种型 | Rabbit |
| 背景介绍 | GRB2 associated binding protein 1(GAB1) Homo sapiens The protein encoded by this gene is a member of the IRS1-like multisubstrate docking protein family. It is an important mediator of branching tubulogenesis and plays a central role in cellular growth response, transformation and apoptosis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008], |
| 细胞定位 | cytosol, |
| 功能 | Function:Probably involved in EGF and insulin receptor signaling.,PTM:Phosphorylated on tyrosine residue(s) by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR). Tyrosine phosphorylation of GAB1 mediates interaction with several proteins that contain SH2 domains.,similarity:Belongs to the GAB family.,similarity:Contains 1 PH domain.,subunit:Interacts with GRB2 and with other SH2-containing proteins. Interacts with phosphorylated LAT2., |
| 纯化 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Clonality | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 修饰类型 | IgG,Kappa |
| 细胞定位 | cytosol, |
| 组织表达 | Testis,Whole embryo, |
| 研究领域 | >>EGFR tyrosine kinase inhibitor resistance;>>ErbB signaling pathway;>>Ras signaling pathway;>>Phospholipase D signaling pathway;>>Neurotrophin signaling pathway;>>Bacterial invasion of epithelial cells;>>Proteoglycans in cancer;>>Renal cell carcinoma;>>Hepatocellular carcinoma;>>Gastric cancer |
周一至周日 8:00-18:00
