| 别名 | Tumor necrosis factor alpha-induced protein 3 |
| 基因名称 | Endogenous |
| 蛋白名称 | TNFAIP3 |
| 推荐应用 | |
| 反应物种 | A20 |
| 存储缓冲液 | IHC 1:200-1:1000;WB 1:2000-1:10000;IF 1:200-1:1000;ELISA 1:5000-1:20000; |
| Human Gene Link | TNFAIP3;OTUD7C;Tumor necrosis factor alpha-induced protein 3;TNF alpha-induced protein 3;OTU domain-containing protein 7C;Putative DNA-binding protein A20;Zinc finger protein A20 |
| Human Swissprot No. | 7128 |
| Mouse Gene ID | P21580 |
| 特异性 | Monoclonal |
| 稀释度 | Unmodified |
| 参考分子量 | 90kD |
| 预测分子量 | WB,IHC,IF,ELISA |
| 运输及保存条件 | Protein A |
| 宿主 | 82kD |
| 同种型 | Rabbit |
| 背景介绍 | This gene was identified as a gene whose expression is rapidly induced by the tumor necrosis factor (TNF). The protein encoded by this gene is a zinc finger protein and ubiqitin-editing enzyme, and has been shown to inhibit NF-kappa B activation as well as TNF-mediated apoptosis. The encoded protein, which has both ubiquitin ligase and deubiquitinase activities, is involved in the cytokine-mediated immune and inflammatory responses. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2012], |
| 细胞定位 | Cytoplasm. Nucleus. Lysosome.; [A20p50]: Cytoplasm. |
| 功能 | Function:Interacts with NAF1 and inhibits TNF-induced NF-kappa-B-dependent gene expression by interfering with an RIP- or TRAF2-mediated transactivation signal. Inhibitor of programmed cell death. Has a role in the function of the lymphoid system and may contribute to the in vivo effects of TNF (By similarity). Has deubiquitinating activity that is directed towards 'Lys-48' or 'Lys-63'-linked polyubiquitin chains.,induction:By TNF-alpha.,similarity:Belongs to the peptidase C64 family.,similarity:Contains 1 OTU domain.,similarity:Contains 7 A20-type zinc fingers.,subunit:Homodimer. Interacts with NAF1, TAX1BP1 and TRAF2., |
| 纯化 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Clonality | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 修饰类型 | IgG,Kappa |
| 细胞定位 | Cytoplasm. Nucleus. Lysosome.; [A20p50]: Cytoplasm. |
| 组织表达 | Epithelium,Testis,Trachea, |
| 研究领域 | >>NF-kappa B signaling pathway;>>Necroptosis;>>NOD-like receptor signaling pathway;>>IL-17 signaling pathway;>>TNF signaling pathway;>>Measles;>>Epstein-Barr virus infection |
周一至周日 8:00-18:00
