| 别名 | High mobility group protein HMGI-C (High mobility group AT-hook protein 2) |
| 基因名称 | Endogenous |
| 蛋白名称 | HMGA2 HMGIC |
| 推荐应用 | |
| 反应物种 | HMGA2 |
| 存储缓冲液 | IHC 1:200-1:1000;WB 1:2000-1:10000;IF 1:200-1:1000;ELISA 1:5000-1:20000; |
| Human Swissprot No. | 8091 |
| Mouse Gene ID | P52926 |
| 特异性 | Monoclonal |
| 稀释度 | Unmodified |
| 参考分子量 | 12kD |
| 预测分子量 | WB,IHC,IF,ELISA |
| 运输及保存条件 | Protein A |
| 宿主 | 18kD |
| 同种型 | Rabbit |
| 背景介绍 | This gene encodes a protein that belongs to the non-histone chromosomal high mobility group (HMG) protein family. HMG proteins function as architectural factors and are essential components of the enhancesome. This protein contains structural DNA-binding domains and may act as a transcriptional regulating factor. Identification of the deletion, amplification, and rearrangement of this gene that are associated with myxoid liposarcoma suggests a role in adipogenesis and mesenchymal differentiation. A gene knock out study of the mouse counterpart demonstrated that this gene is involved in diet-induced obesity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008], |
| 细胞定位 | Nucleus. |
| 功能 | developmental stage:Expressed predominantly during embryogenesis.,Disease:A chromosomal aberration involving HMGA2 is associated with a subclass of benign mesenchymal tumors known as lipomas. Translocation t(3;12)(q27-q28;q13-q15) with LPP is shown in lipomas. HMGA2 is also fused with a number of other genes in lipomas.,Disease:A chromosomal aberration involving HMGA2 is associated with parosteal lipomas. Translocation t(3;12)(q28;q14) with LPP is also shown in one parosteal lipoma.,Disease:A chromosomal aberration involving HMGA2 is associated with pulmonary chondroid hamartomas. Translocation t(3;12)(q27-q28;q14-q15) with LPP is detected in pulmonary chondroid hamartomas.,Disease:A chromosomal aberration involving HMGA2 is found in uterine leiomyoma (UL) [MIM:150699]. Translocation t(12;14)(q15;q23-24) with RAD51L1. Chromosomal rearrangements involving HMGA2 do not seem to be the principle pathobiological mechanism in uterine leiomyoma.,Function:Functions as a transcriptional regulator. Functions in cell cycle regulation through CCNA2.,polymorphism:Genetic variation in HMGA2 has been associated with stature as a quantitative trait (STQTL9) [MIM:611547]. Human height is a classic, highly heritable quantitative trait.,PTM:Regulated by cell cycle-dependent phosphorylation which alters its DNA binding affinity.,similarity:Belongs to the HMGA family.,similarity:Contains 3 A.T hook DNA-binding domains.,subunit:Interacts with E4F1., |
| 纯化 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Clonality | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 修饰类型 | IgG,Kappa |
| 细胞定位 | Nucleus. |
| 组织表达 | Aorta endothelial cell,Hepatoma, |
| 研究领域 | >>Transcriptional misregulation in cancer;>>MicroRNAs in cancer |
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