| 别名 | Deoxyhypusine hydroxylase;hDOHH;Deoxyhypusine dioxygenase;Deoxyhypusine monooxygenase;HEAT-like repeat-containing protein 1; |
| 基因名称 | Endogenous |
| 蛋白名称 | DOHH;HLRC1 |
| 推荐应用 | |
| 反应物种 | DOHH |
| 存储缓冲液 | WB 1:1000-5000;IP 1:50-100 |
| Human Gene Link | DOHH;HLRC1;Deoxyhypusine hydroxylase ;hDOHH;Deoxyhypusine dioxygenase;Deoxyhypusine monooxygenase;HEAT-like repeat-containing protein 1; |
| Human Swissprot No. | 83475 |
| Mouse Gene ID | Q9BU89 |
| 特异性 | Monoclonal |
| 稀释度 | Unmodified |
| 预测分子量 | WB,IP |
| 运输及保存条件 | Protein A |
| 宿主 | 33kD |
| 同种型 | Rabbit |
| 背景介绍 | This gene encodes a metalloenzyme that catalyzes the last step in the conversion of lysine to the unique amino acid hypusine in eukaryotic initiation factor 5A. The encoded protein hydroxylates deoxyhypusine to form hypusine in the mature eukaryotic initiation factor 5A protein. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Feb 2009] |
| 功能 | Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate produced by deoxyhypusine synthase/DHPS on a critical lysine of the eukaryotic translation initiation factor 5A/eIF-5A. This is the second step of the post-translational modification of that lysine into an unusual amino acid residue named hypusine (PubMed:16371467, PubMed:16533814, PubMed:19706422). Hypusination is unique to mature eIF-5A factor and is essential for its function (By similarity). {ECO:0000250|UniProtKB:Q99LN9, ECO:0000255|HAMAP-Rule:MF_03101, ECO:0000269|PubMed:16371467, ECO:0000269|PubMed:16533814, ECO:0000269|PubMed:19706422}. |
| 纯化 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Clonality | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 修饰类型 | IgG,Kappa |
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