| 别名 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1;Complex I-MWFE;CI-MWFE;NADH-ubiquinone oxidoreductase MWFE subunit; |
| 基因名称 | Endogenous |
| 蛋白名称 | NDUFA1 |
| 推荐应用 | |
| 反应物种 | NDUFA1 |
| 存储缓冲液 | WB 1:1000-5000;IHC 1:100-300;IP 1:50-100 |
| Human Gene Link | NDUFA1;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 ;Complex I-MWFE;CI-MWFE;NADH-ubiquinone oxidoreductase MWFE subunit; |
| Human Swissprot No. | 4694 |
| Mouse Gene ID | O15239 |
| 特异性 | Monoclonal |
| 稀释度 | Unmodified |
| 预测分子量 | WB,IHC,IP |
| 运输及保存条件 | Protein A |
| 宿主 | 8kD |
| 同种型 | Rabbit |
| 背景介绍 | The human NDUFA1 gene codes for an essential component of complex I of the respiratory chain, which transfers electrons from NADH to ubiquinone. It has been noted that the N-terminal hydrophobic domain has the potential to be folded into an alpha-helix spanning the inner mitochondrial membrane with a C-terminal hydrophilic domain interacting with globular subunits of complex I. The highly conserved two-domain structure suggests that this feature is critical for the protein function and might act as an anchor for the NADH:ubiquinone oxidoreductase complex at the inner mitochondrial membrane. However, the NDUFA1 peptide is one of about 31 components of the "hydrophobic protein" (HP) fraction of complex I which is involved in proton translocation. Thus the NDUFA1 peptide may also participate in that function. [provided by RefSeq, Jul 2008], |
| 细胞定位 | Mitochondrion inner membrane; Single-pass membrane protein; Matrix side. |
| 功能 | Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. {ECO:0000269|PubMed:27626371}. |
| 纯化 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Clonality | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 修饰类型 | IgG,Kappa |
| 细胞定位 | Mitochondrion inner membrane; Single-pass membrane protein; Matrix side. |
| 组织表达 | Primarily expressed in heart and skeletal muscle. |
| 研究领域 | >>Oxidative phosphorylation;>>Metabolic pathways;>>Thermogenesis;>>Retrograde endocannabinoid signaling;>>Non-alcoholic fatty liver disease;>>Alzheimer disease;>>Parkinson disease;>>Amyotrophic lateral sclerosis;>>Huntington disease;>>Prion disease;>>Pathways of neurodegeneration - multiple diseases;>>Chemical carcinogenesis - reactive oxygen species;>>Diabetic cardiomyopathy |
周一至周日 8:00-18:00
