| 别名 | Sodium- and chloride-dependent glycine transporter 2 (GlyT-2) (GlyT2) (Solute carrier family 6 member 5) |
| 基因名称 | Endogenous |
| 蛋白名称 | SLC6A5,GLYT2,NET1 |
| 推荐应用 | |
| 反应物种 | Glyt2 |
| 存储缓冲液 | WB 1:1000-1:5000; |
| Human Gene Link | GLYT2 NET1 |
| Human Swissprot No. | 9152 |
| Mouse Gene ID | Q9Y345 |
| Mouse Swissprot No. | 104245 |
| Rat Gene ID | 171148 |
| Rat Swissprot No. | P58295 |
| 特异性 | Monoclonal |
| 稀释度 | Unmodified |
| 参考分子量 | 88kDa |
| 预测分子量 | WB |
| 运输及保存条件 | Protein A |
| 宿主 | 88kDa |
| 同种型 | Rabbit |
| 背景介绍 | This gene encodes a sodium- and chloride-dependent glycine neurotransmitter transporter. This integral membrane glycoprotein is responsible for the clearance of extracellular glycine during glycine-mediated neurotransmission. This protein is found in glycinergic axons and maintains a high presynaptic pool of neurotransmitter at glycinergic synapses. Mutations in this gene cause hyperekplexia; a heterogenous neurological disorder characterized by exaggerated startle responses and neonatal apnea. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016] |
| 细胞定位 | SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:16751771, ECO:0000269|PubMed:31370103}; Multi-pass membrane protein {ECO:0000255}. |
| 功能 | FUNCTION: Sodium- and chloride-dependent glycine transporter (PubMed:10381548, PubMed:10606742, PubMed:16751771, PubMed:31370103, PubMed:9845349). Terminates the action of glycine by its high affinity sodium-dependent reuptake into presynaptic terminals (PubMed:9845349). May be responsible for the termination of neurotransmission at strychnine-sensitive glycinergic synapses (PubMed:9845349). {ECO:0000269|PubMed:10381548, ECO:0000269|PubMed:10606742, ECO:0000269|PubMed:16751771, ECO:0000269|PubMed:31370103, ECO:0000269|PubMed:9845349}.; FUNCTION: [Isoform 2]: Lacks sodium- and chloride-dependent glycine transporter activity. {ECO:0000269|PubMed:10381548}.; FUNCTION: [Isoform 3]: Lacks sodium- and chloride-dependent glycine transporter activity. {ECO:0000269|PubMed:10381548}. |
| 纯化 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Clonality | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 修饰类型 | IgG,Kappa |
| 细胞定位 | SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:16751771, ECO:0000269|PubMed:31370103}; Multi-pass membrane protein {ECO:0000255}. |
| 组织表达 | TISSUE SPECIFICITY: Expressed in medulla, and to a lesser extent in spinal cord and cerebellum. {ECO:0000269|PubMed:9845349}. |
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