| 别名 | C-type lectin domain family 2 member B (Activation-induced C-type lectin) (C-type lectin superfamily member 2) (IFN-alpha-2b-inducing-related protein 1) |
| 基因名称 | Endogenous |
| 蛋白名称 | CLEC2B,AICL,CLECSF2,IFNRG1 |
| 推荐应用 | |
| 反应物种 | CLEC2B |
| 存储缓冲液 | IHC 1:200-1:1000;WB 1:2000-1:10000;IF 1:200-1:1000;ELISA 1:5000-1:20000; |
| Human Gene Link | AICL CLECSF2 IFNRG1 |
| Human Swissprot No. | 9976 |
| Mouse Gene ID | Q92478 |
| 特异性 | Monoclonal |
| 稀释度 | Unmodified |
| 参考分子量 | 16kDa |
| 预测分子量 | WB,IHC,IF,ELISA |
| 运输及保存条件 | Protein A |
| 宿主 | 16kDa |
| 同种型 | Rabbit |
| 背景介绍 | Natural killer (NK) cells express multiple calcium-dependent (C-type) lectin-like receptors, such as CD94 (KLRD1; MIM 602894) and NKG2D (KLRC4; MIM 602893), that interact with major histocompatibility complex class I molecules and either inhibit or activate cytotoxicity and cytokine secretion. CLEC2 is a C-type lectin-like receptor expressed in myeloid cells and NK cells (Colonna et al., 2000 [PubMed 10671229]).[supplied by OMIM, Jan 2011] |
| 细胞定位 | SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:23929856, ECO:0000269|PubMed:29980609}; Single-pass type II membrane protein {ECO:0000305}. Golgi apparatus membrane {ECO:0000269|PubMed:23929856}. Note=Resting NK cells contain intracellular stores of CLEC2B associated with the Golgi complex. {ECO:0000269|PubMed:23929856}. |
| 功能 | FUNCTION: Membrane-bound protein expressed on myeloid cells which acts as a ligand to stimulate the activating receptor NKp80/KLRF1, expressed on the surface of natural killer (NK) cells. In turn, stimulates NK-cell cytotoxicity and cytokine production leading to the cytolysis of malignant CLEC2B-expressing myeloid cells. {ECO:0000269|PubMed:17057721, ECO:0000269|PubMed:18230726, ECO:0000269|PubMed:23929856}. |
| 纯化 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Clonality | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 修饰类型 | IgG,Kappa |
| 细胞定位 | SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:23929856, ECO:0000269|PubMed:29980609}; Single-pass type II membrane protein {ECO:0000305}. Golgi apparatus membrane {ECO:0000269|PubMed:23929856}. Note=Resting NK cells contain intracellular stores of CLEC2B associated with the Golgi complex. {ECO:0000269|PubMed:23929856}. |
| 组织表达 | TISSUE SPECIFICITY: Expressed preferentially in lymphoid tissues, and in most hematopoietic cell types. |
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