| 别名 | Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (Cam-PDE 1B) (63 kDa Cam-PDE) |
| 基因名称 | Endogenous |
| 蛋白名称 | PDE1B PDE1B1 PDES1B |
| 推荐应用 | |
| 反应物种 | PDE1B |
| 存储缓冲液 | IHC 1:200-1:1000;WB 1:1000-1:5000; |
| Human Swissprot No. | 5153 |
| Mouse Gene ID | Q01064 |
| Rat Swissprot No. | Q01066 |
| 特异性 | Monoclonal |
| 稀释度 | Unmodified |
| 参考分子量 | 59kDa |
| 预测分子量 | WB,IHC |
| 运输及保存条件 | Protein A |
| 宿主 | 59kDa |
| 同种型 | Rabbit |
| 背景介绍 | The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE1 subfamily. Members of the PDE1 family are calmodulin-dependent PDEs that are stimulated by a calcium-calmodulin complex. This PDE has dual-specificity for the second messengers, cAMP and cGMP, with a preference for cGMP as a substrate. cAMP and cGMP function as key regulators of many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011], |
| 细胞定位 | Cytoplasm, cytosol . |
| 功能 | Catalytic activity:Nucleoside 3',5'-cyclic phosphate + H(2)O = nucleoside 5'-phosphate.,enzyme regulation:Type I PDE are activated by the binding of calmodulin in the presence of Ca(2+).,Function:Has a preference for cGMP as a substrate.,similarity:Belongs to the cyclic nucleotide phosphodiesterase family.,subunit:Homodimer., |
| 纯化 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Clonality | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 修饰类型 | IgG,Kappa |
| 细胞定位 | Cytoplasm, cytosol . |
| 组织表达 | Brain,Human uterus,Testis, |
| 研究领域 | >>Purine metabolism;>>Metabolic pathways;>>Calcium signaling pathway;>>Olfactory transduction;>>Taste transduction;>>Renin secretion;>>Morphine addiction |
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