| 别名 | Tetraspanin-4 (Tspan-4) (Novel antigen 2) (NAG-2) (Transmembrane 4 superfamily member 7) |
| 基因名称 | Endogenous |
| 蛋白名称 | TSPAN4,NAG2,TM4SF7 |
| 推荐应用 | |
| 反应物种 | NAG-2 |
| 存储缓冲液 | WB 1:1000-1:5000; |
| Human Gene Link | NAG2 TM4SF7 |
| Human Swissprot No. | 7106 |
| Mouse Gene ID | O14817 |
| Mouse Swissprot No. | 64540 |
| 特异性 | Monoclonal |
| 稀释度 | Unmodified |
| 参考分子量 | 26kDa |
| 预测分子量 | WB |
| 运输及保存条件 | Protein A |
| 宿主 | 26kDa |
| 同种型 | Rabbit |
| 背景介绍 | The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein and is similar in sequence to its family member CD53 antigen. It is known to complex with integrins and other transmembrane 4 superfamily proteins. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008] |
| 细胞定位 | SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:25342562, ECO:0000269|PubMed:34439793}; Multi-pass membrane protein. |
| 功能 | FUNCTION: Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling. Plays an essential role in migrasome formation and migration on retracting fibers at the rear end of migrating cells (PubMed:31371828). Migrasomes are cellular organelles that form as large vesicle-like structures on retraction fibers of migrating cells (PubMed:31371828). Mechanistically, acts as a membrane curvature sensor and participates in stabilizing the migrasome structure in a late stage of biogenesis (PubMed:36252000, PubMed:36823145). May also play a regulatory role for the histamine H4 receptor/HRH4 without affecting histamine binding to HRH4 or signaling (PubMed:34439793). {ECO:0000269|PubMed:31371828, ECO:0000269|PubMed:34439793, ECO:0000269|PubMed:36252000, ECO:0000269|PubMed:36823145}. |
| 纯化 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Clonality | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 修饰类型 | IgG,Kappa |
| 细胞定位 | SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:25342562, ECO:0000269|PubMed:34439793}; Multi-pass membrane protein. |
| 组织表达 | TISSUE SPECIFICITY: Expressed in multiple tissues but is absent in brain, lymphoid cells, and platelets. |
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