| 别名 | Mitochondrial S-adenosylmethionine carrier protein (SAM carrier) (Solute carrier family 25 member 26) |
| 基因名称 | Endogenous |
| 蛋白名称 | SLC25A26,SAMC |
| 推荐应用 | |
| 反应物种 | SLC25A26 |
| 存储缓冲液 | WB 1:1000-1:5000; |
| Human Gene Link | SAMC |
| Human Swissprot No. | 115286 |
| Mouse Gene ID | Q70HW3 |
| Mouse Swissprot No. | 57279 |
| 特异性 | Monoclonal |
| 稀释度 | Unmodified |
| 参考分子量 | 30kDa |
| 预测分子量 | WB |
| 运输及保存条件 | Protein A |
| 宿主 | 30kDa |
| 同种型 | Rabbit |
| 背景介绍 | This gene product is one of several closely related mitochondrial-membrane carrier proteins that shuttle substrates between cytosol and the intramitochondrial matrix space. This protein mediates the transport of acylcarnitines into mitochondrial matrix for their oxidation by the mitochondrial fatty acid-oxidation pathway. Mutations in this gene are associated with carnitine-acylcarnitine translocase deficiency, which can cause a variety of pathological conditions such as hypoglycemia, cardiac arrest, hepatomegaly, hepatic dysfunction and muscle weakness, and is usually lethal in new born and infants. [provided by RefSeq, Jul 2008] |
| 细胞定位 | SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000305|PubMed:14674884, ECO:0000305|PubMed:26522469}; Multi-pass membrane protein {ECO:0000255}. |
| 功能 | FUNCTION: Mitochondrial S-adenosyl-L-methionine/S-adenosyl-L-homocysteine antiporter. Mediates the exchange of cytosolic S-adenosyl-L-methionine, the predominant methyl-group donor for macromolecule methylation processes, for mitochondrial S-adenosylhomocysteine(SAH), a by-product of methylation reactions. {ECO:0000269|PubMed:14674884, ECO:0000269|PubMed:26522469, ECO:0000269|PubMed:35024855}. |
| 纯化 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Clonality | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 修饰类型 | IgG,Kappa |
| 细胞定位 | SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000305|PubMed:14674884, ECO:0000305|PubMed:26522469}; Multi-pass membrane protein {ECO:0000255}. |
| 组织表达 | TISSUE SPECIFICITY: Widely expressed. Highly expressed in testis, with moderate expression in brain, heart, kidney, lung, skeletal muscle, pancreas, small intestine and liver, and low expression in spleen. {ECO:0000269|PubMed:14674884}. |
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