| 别名 | BTB/POZ domain-containing protein KCTD21 (KCASH2 protein) (Potassium channel tetramerization domain-containing protein 21) |
| 基因名称 | Endogenous |
| 蛋白名称 | KCTD21 |
| 推荐应用 | |
| 反应物种 | KCTD21 |
| 存储缓冲液 | WB 1:1000-1:5000;FC 1:100-1:500; |
| Human Swissprot No. | 283219 |
| Mouse Gene ID | Q4G0X4 |
| Mouse Swissprot No. | 622320 |
| 特异性 | Monoclonal |
| 稀释度 | Unmodified |
| 参考分子量 | 29kDa |
| 预测分子量 | WB,FC |
| 运输及保存条件 | Protein A |
| 宿主 | 29kDa |
| 同种型 | Rabbit |
| 背景介绍 | Enables cullin family protein binding activity; histone deacetylase binding activity; and identical protein binding activity. Involved in negative regulation of smoothened signaling pathway and ubiquitin-dependent protein catabolic process. [provided by Alliance of Genome Resources, Apr 2025] |
| 功能 | FUNCTION: Probable substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex mediating the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes the ubiquitination of HDAC1. Can function as antagonist of the Hedgehog pathway by affecting the nuclear transfer of transcription factor GLI1; the function probably occurs via HDAC1 down-regulation, keeping GLI1 acetylated and inactive. Inhibits cell growth and tumorigenicity of medulloblastoma (MDB) (PubMed:21472142). {ECO:0000269|PubMed:21472142}. |
| 纯化 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Clonality | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 修饰类型 | IgG,Kappa |
| 组织表达 | TISSUE SPECIFICITY: Highly expressed in cerebellum and brain. Expression is down-regulated in medulloblastoma. {ECO:0000269|PubMed:21472142}. |
周一至周日 8:00-18:00
