| 别名 | Inositol 1,4,5-triphosphate receptor associated 2;Lymphoid-restricted membrane protein;Protein Jaw1; [Cleaved into: Processed inositol 1,4,5-triphosphate receptor associated 2] |
| 基因名称 | Endogenous |
| 蛋白名称 | IRAG2;JAW1;LRMP |
| 推荐应用 | |
| 反应物种 | IRAG2 |
| 存储缓冲液 | WB 1:1000-5000;IHC 1:100-300;ICC/IF 1:100-300;FC 1:100-300 |
| Human Gene Link | IRAG2;JAW1;LRMP;Inositol 1,4,5-triphosphate receptor associated 2 ;Lymphoid-restricted membrane protein;Protein Jaw1; [Cleaved into: Processed inositol 1,4,5-triphosphate receptor associated 2]; |
| Human Swissprot No. | 4033 |
| Mouse Gene ID | Q12912 |
| 特异性 | Monoclonal |
| 稀释度 | Unmodified |
| 预测分子量 | WB,IHC,IF,ICC,FC |
| 运输及保存条件 | Protein A |
| 宿主 | 61kD |
| 同种型 | Rabbit |
| 背景介绍 | The protein encode dby this gene is expressed in a developmentally regulated manner in lymphoid cell lines and tissues. The protein is localized to the cytoplasmic face of the endoplasmic reticulum. [provided by RefSeq, Jul 2008] |
| 细胞定位 | [Processed inositol 1,4,5-triphosphate receptor associated 2]: Cytoplasm.; Endoplasmic reticulum membrane; Single-pass type IV membrane protein. Nucleus envelope. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Chromosome. Note=Colocalized with ITPR3 on the endoplasmic reticulum membrane.. |
| 功能 | Plays a role in the delivery of peptides to major histocompatibility complex (MHC) class I molecules; this occurs in a transporter associated with antigen processing (TAP)-independent manner. May play a role in taste signal transduction via ITPR3. May play a role during fertilization in pronucleus congression and fusion. Plays a role in maintaining nuclear shape, maybe as a component of the LINC complex and through interaction with microtubules. Plays a role in the regulation of cellular excitability by regulating the hyperpolarization-activated cyclic nucleotide-gated HCN4 channel activity (By similarity). {ECO:0000250|UniProtKB:Q60664}. |
| 纯化 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Clonality | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 修饰类型 | IgG,Kappa |
| 细胞定位 | [Processed inositol 1,4,5-triphosphate receptor associated 2]: Cytoplasm.; Endoplasmic reticulum membrane; Single-pass type IV membrane protein. Nucleus envelope. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Chromosome. Note=Colocalized with ITPR3 on the endoplasmic reticulum membrane.. |
| 组织表达 | Expressed at high levels in pre B-cells, mature B-cells and pre T-cells. Expressed at low levels in mature T-cells and plasma B-cells. Expressed in germinal center B-cells, splenic marginal zone cells and B-cell lymphomas. Expressed in neuronal cells in the cerebral cortex, epithelial cells in tonsil, adrenal glands, zymogen-producing cells in the stomach and epithelial cells in seminal vesicles. {ECO:0000269|PubMed:16739114, ECO:0000269|PubMed:8021504}. |
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