| 别名 | Insulin gene enhancer protein ISL-1 |
| 基因名称 | Endogenous |
| 蛋白名称 | ISL1 |
| 推荐应用 | |
| 反应物种 | Islet-1 |
| 存储缓冲液 | IHC 1:200-1:1000;WB 1:2000-1:10000;IF 1:200-1:1000;ELISA 1:5000-1:20000;IP 1:50-1:200; |
| Human Gene Link | ISL1;Insulin gene enhancer protein ISL-1;Islet-1 |
| Human Swissprot No. | 3670 |
| Mouse Gene ID | P61371 |
| 特异性 | Monoclonal |
| 稀释度 | Unmodified |
| 参考分子量 | 39kD |
| 预测分子量 | WB,IHC,IF,IP,ELISA |
| 运输及保存条件 | Protein A |
| 宿主 | 39kD |
| 同种型 | Rabbit |
| 背景介绍 | This gene encodes a member of the LIM/homeodomain family of transcription factors. The encoded protein binds to the enhancer region of the insulin gene, among others, and may play an important role in regulating insulin gene expression. The encoded protein is central to the development of pancreatic cell lineages and may also be required for motor neuron generation. Mutations in this gene have been associated with maturity-onset diabetes of the young. [provided by RefSeq, Jul 2008], |
| 细胞定位 | Nucleus . |
| 功能 | Function:Binds to one of the cis-acting domain of the insulin gene enhancer.,similarity:Contains 1 homeobox DNA-binding domain.,similarity:Contains 2 LIM zinc-binding domains.,tissue specificity:Expressed in subsets of neurons of the adrenal medulla and dorsal root ganglion, inner nuclear and ganglion cell layers in the retina, the pineal and some regions of the brain., |
| 纯化 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Clonality | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 修饰类型 | IgG,Kappa |
| 细胞定位 | Nucleus . |
| 组织表达 | Expressed in subsets of neurons of the adrenal medulla and dorsal root ganglion, inner nuclear and ganglion cell layers in the retina, the pineal and some regions of the brain. |
| 研究领域 | >>Signaling pathways regulating pluripotency of stem cells |
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