| 别名 | Chromodomain-helicase-DNA-binding protein 4 |
| 基因名称 | Endogenous |
| 蛋白名称 | CHD4 |
| 推荐应用 | |
| 反应物种 | CHD4 |
| 存储缓冲液 | WB 1:2000-1:10000;IF 1:200-1:1000;ELISA 1:5000-1:20000; |
| Human Gene Link | CHD4;Chromodomain-helicase-DNA-binding protein 4;CHD-4;ATP-dependent helicase CHD4;Mi-2 autoantigen 218 kDa protein;Mi2-beta |
| Human Swissprot No. | 1108 |
| Mouse Gene ID | Q14839 |
| Mouse Swissprot No. | 107932 |
| 特异性 | Monoclonal |
| 稀释度 | Unmodified |
| 参考分子量 | 218kD |
| 预测分子量 | WB,IF,ELISA |
| 运输及保存条件 | Protein A |
| 宿主 | 260kD |
| 同种型 | Rabbit |
| 背景介绍 | The product of this gene belongs to the SNF2/RAD54 helicase family. It represents the main component of the nucleosome remodeling and deacetylase complex and plays an important role in epigenetic transcriptional repression. Patients with dermatomyositis develop antibodies against this protein. Somatic mutations in this gene are associated with serous endometrial tumors. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014], |
| 细胞定位 | Nucleus . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Associates with centrosomes in interphase. . |
| 功能 | Disease:One of the main antigens reacting with anti-MI-2 positive sera of dermatomyositis.,Function:Probable transcription regulator.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the SNF2/RAD54 helicase family.,similarity:Contains 1 helicase ATP-binding domain.,similarity:Contains 1 helicase C-terminal domain.,similarity:Contains 2 chromo domains.,similarity:Contains 2 PHD-type zinc fingers.,subunit:Central component of the nucleosome remodeling and histone deacetylase (NuRD) repressor complex. Interacts with TRIM27. Part of a complex containing ATR and HDAC2. Interacts with KLF1; the interaction depends on sumoylation of KLF1, and leads to its transcriptional repression., |
| 纯化 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Clonality | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 修饰类型 | IgG,Kappa |
| 细胞定位 | Nucleus . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Associates with centrosomes in interphase. . |
| 组织表达 | Epithelium,Pancreas,Skin,Uterus, |
| 研究领域 | >>Human papillomavirus infection;>>Viral carcinogenesis |
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