| 别名 | Serine/threonine-protein kinase 13/Aurora kinase C |
| 基因名称 | Endogenous |
| 蛋白名称 | AURKC |
| 推荐应用 | |
| 反应物种 | AurC |
| 存储缓冲液 | WB 1:500-1:2000;IF 1:200-1:1000;ELISA 1:5000-1:20000; |
| Human Gene Link | AIE2;AIK3;AIRK3;ARK3;STK13;Aurora kinase C;Aurora 3;Aurora/IPL1 related kinase 3;ARK 3;Aurora related kinase 3;Serine/threonine protein kinase 13;Aurora/IPL1related kinase 3;Aurorarelated kinase 3;Serine/threonineprotein kinase 13;Serine/threonineprotein kinase auroraC; |
| Human Swissprot No. | 6795 |
| Mouse Gene ID | Q9UQB9 |
| 特异性 | Monoclonal |
| 稀释度 | Unmodified |
| 参考分子量 | 36kD |
| 预测分子量 | WB,IF,ELISA |
| 运输及保存条件 | Protein A |
| 宿主 | 36kD |
| 同种型 | Rabbit |
| 背景介绍 | This gene encodes a member of the Aurora subfamily of serine/threonine protein kinases. The encoded protein is a chromosomal passenger protein that forms complexes with Aurora-B and inner centromere proteins and may play a role in organizing microtubules in relation to centrosome/spindle function during mitosis. This gene is overexpressed in several cancer cell lines, suggesting an involvement in oncogenic signal transduction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008] |
| 细胞定位 | Nucleus,Chromosome,Chromosome, centromere,Cytoplasm, cytoskeleton, spindle,Note: Distributes in the condensed chromosomes during prophase to metaphase. After entering anaphase, there is a dissociation from separated chromosomes and a redistribution to midzone microtubules, and finally remains in the midbody during cytokinesis. |
| 功能 | Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Also plays a role in meiosis and more particularly in spermatogenesis. Has redundant cellular functions with AURKB and can rescue an AURKB knockdown. Like AURKB, AURKC phosphorylates histone H3 at 'Ser-10' and 'Ser-28'. AURKC phosphorylates the CPC complex subunits BIRC5/survivin and INCENP leading to increased AURKC activity. Phosphorylates TACC1, another protein involved in cell division, at 'Ser-228'. |
| 纯化 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Clonality | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 修饰类型 | IgG,Kappa |
| 细胞定位 | Nucleus,Chromosome,Chromosome, centromere,Cytoplasm, cytoskeleton, spindle,Note: Distributes in the condensed chromosomes during prophase to metaphase. After entering anaphase, there is a dissociation from separated chromosomes and a redistribution to midzone microtubules, and finally remains in the midbody during cytokinesis. |
| 组织表达 | Tissue specificity:Isoform 1 and isoform 2 are expressed in testis. Elevated expression levels were seen only in a subset of cancer cell lines such as Hep-G2, Huh-7 and HeLa. Expression is maximum at M phase.Induction:Expression is cell cycle-regulated, with an increase during G2 and M phases. |
周一至周日 8:00-18:00
