| 别名 | Phosphoglycerate kinase 1 (Cell migration-inducing gene 10 protein) (Primer recognition protein 2) (PRP 2) |
| 基因名称 | Endogenous |
| 蛋白名称 | PGK1 PGKA MIG10 OK/SW-cl.110 |
| 推荐应用 | |
| 反应物种 | PGK1 |
| 存储缓冲液 | IHC 1:1000-1:4000;WB 1:2000-1:10000;IF 1:200-1:1000;ELISA 1:5000-1:20000; |
| Human Gene Link | Phosphoglycerate kinase 1;Cell migration-inducing gene 10 protein;Primer recognition protein 2;PRP 2; |
| Human Swissprot No. | 5230 |
| Mouse Gene ID | P00558 |
| Mouse Swissprot No. | 18655 |
| Rat Gene ID | 24644 |
| Rat Swissprot No. | P16617 |
| 特异性 | Monoclonal |
| 稀释度 | Unmodified |
| 参考分子量 | 45kD |
| 预测分子量 | WB,IHC,IF,ELISA |
| 运输及保存条件 | Protein A |
| 宿主 | 45kD |
| 同种型 | Rabbit |
| 背景介绍 | The protein encoded by this gene is a glycolytic enzyme that catalyzes the conversion of 1,3-diphosphoglycerate to 3-phosphoglycerate. The encoded protein may also act as a cofactor for polymerase alpha. Additionally, this protein is secreted by tumor cells where it participates in angiogenesis by functioning to reduce disulfide bonds in the serine protease, plasmin, which consequently leads to the release of the tumor blood vessel inhibitor angiostatin. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Deficiency of the enzyme is associated with a wide range of clinical phenotypes hemolytic anemia and neurological impairment. Pseudogenes of this gene have been defined on chromosomes 19, 21 and the X chromosome. [provided by RefSeq, Jan 2014] |
| 细胞定位 | Cytoplasm. |
| 功能 | Catalyzes one of the two ATP producing reactions in the glycolytic pathway via the reversible conversion of 1,3-diphosphoglycerate to 3-phosphoglycerate . In addition to its role as a glycolytic enzyme, it seems that PGK-1 acts as a polymerase alpha cofactor protein (primer recognition protein) . May play a role in sperm motility . |
| 纯化 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Clonality | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 修饰类型 | IgG,Kappa |
| 细胞定位 | Cytoplasm. |
| 组织表达 | Mainly expressed in spermatogonia. Localized on the principle piece in the sperm (at protein level). Expression significantly decreased in the testis of elderly men. |
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