| 别名 | Plasminogen activator inhibitor 1 |
| 基因名称 | Endogenous |
| 蛋白名称 | SERPINE1 |
| 推荐应用 | |
| 反应物种 | PAI-1 |
| 存储缓冲液 | IHC 1:200-1:1000;WB 1:2000-1:10000;IF 1:200-1:1000;ELISA 1:5000-1:20000;IP 1:50-1:200; |
| Human Gene Link | SERPINE1;PAI1;PLANH1;Plasminogen activator inhibitor 1;PAI;PAI-1;Endothelial plasminogen activator inhibitor;Serpin E1 |
| Human Swissprot No. | 5054 |
| Mouse Gene ID | P05121 |
| Rat Gene ID | 24617 |
| Rat Swissprot No. | P20961 |
| 特异性 | Monoclonal |
| 稀释度 | Unmodified |
| 参考分子量 | 45kD |
| 预测分子量 | WB,IHC,IF,IP,ELISA |
| 运输及保存条件 | Protein A |
| 宿主 | 45kD |
| 同种型 | Rabbit |
| 背景介绍 | This gene encodes a member of the serine proteinase inhibitor (serpin) superfamily. This member is the principal inhibitor of tissue plasminogen activator (tPA) and urokinase (uPA), and hence is an inhibitor of fibrinolysis. Defects in this gene are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1 deficiency), and high concentrations of the gene product are associated with thrombophilia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009], |
| 细胞定位 | Secreted . |
| 功能 | Disease:Defects in SERPINE1 are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1 deficiency) [MIM:173360]. This deficiency is characterized by abnormal bleeding due to SERPINE1 defect in the plasma.,Disease:High concentrations of SERPINE1 have been associated with thrombophilia [MIM:188050]; an autosomal dominant disorder in which affected individuals are prone to develop serious spontaneous thrombosis.,Function:This inhibitor acts as 'bait' for tissue plasminogen activator, urokinase, and protein C. Its rapid interaction with TPA may function as a major control point in the regulation of fibrinolysis.,online information:Plasminogen activator inhibitor-1 entry,PTM:Inactivated by proteolytic attack of the urokinase-type (u-PA) and the tissue-type (TPA), cleaving the 369-Arg-|-Met-370 bond.,similarity:Belongs to the serpin family.,subunit:Interacts with VTN. Binds LRP1B; binding is followed by internalization and degradation.,tissue specificity:Found in plasma and platelets and in endothelial, hepatoma and fibrosarcoma cells., |
| 纯化 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Clonality | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 修饰类型 | IgG,Kappa |
| 细胞定位 | Secreted . |
| 组织表达 | Expressed in endothelial cells (PubMed:2430793, PubMed:3097076). Found in plasma, platelets, and hepatoma and fibrosarcoma cells. |
| 研究领域 | >>HIF-1 signaling pathway;>>p53 signaling pathway;>>Cellular senescence;>>Apelin signaling pathway;>>Hippo signaling pathway;>>Complement and coagulation cascades;>>AGE-RAGE signaling pathway in diabetic complications;>>Chagas disease |
周一至周日 8:00-18:00
