| 别名 | Nuclear receptor subfamily 4 group A member 1 |
| 基因名称 | Endogenous |
| 蛋白名称 | NR4A1 |
| 推荐应用 | |
| 反应物种 | Nur77 |
| 存储缓冲液 | WB 1:2000-1:10000;IF 1:200-1:1000;ELISA 1:5000-1:20000; |
| Human Gene Link | NR4A1;GFRP1;HMR;NAK1;Nuclear receptor subfamily 4 group A member 1;Early response protein NAK1;Nuclear hormone receptor NUR/77;Nur77;Orphan nuclear receptor HMR;Orphan nuclear receptor TR3;ST-59;Testicular receptor 3 |
| Human Swissprot No. | 3164 |
| Mouse Gene ID | P22736 |
| Mouse Swissprot No. | 15370 |
| Rat Gene ID | 79240 |
| Rat Swissprot No. | P22829 |
| 特异性 | Monoclonal |
| 稀释度 | Unmodified |
| 参考分子量 | 65kD |
| 预测分子量 | WB,IF,ELISA |
| 运输及保存条件 | Protein A |
| 宿主 | 65kD |
| 同种型 | Rabbit |
| 背景介绍 | This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. Expression is induced by phytohemagglutinin in human lymphocytes and by serum stimulation of arrested fibroblasts. The encoded protein acts as a nuclear transcription factor. Translocation of the protein from the nucleus to mitochondria induces apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011], |
| 细胞定位 | Nucleus . Cytoplasm . Mitochondrion . Nuclear export to the cytoplasm is XPO1-mediated and positively regulated by IFI27 (PubMed:22427340). Translocation to the mitochondrion upon interaction with RXRA and upon the presence of 9-cis retinoic acid (PubMed:17761950). . |
| 功能 | Function:Orphan nuclear receptor.,induction:By growth-stimulating agents.,similarity:Belongs to the nuclear hormone receptor family.,similarity:Belongs to the nuclear hormone receptor family. NR4 subfamily.,similarity:Contains 1 nuclear receptor DNA-binding domain.,subunit:Interacts with GADD45GIP1.,tissue specificity:Fetal muscle and adult liver, brain and thyroid., |
| 纯化 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Clonality | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 修饰类型 | IgG,Kappa |
| 细胞定位 | Nucleus . Cytoplasm . Mitochondrion . Nuclear export to the cytoplasm is XPO1-mediated and positively regulated by IFI27 (PubMed:22427340). Translocation to the mitochondrion upon interaction with RXRA and upon the presence of 9-cis retinoic acid (PubMed:17761950). . |
| 组织表达 | Fetal muscle and adult liver, brain and thyroid. |
| 研究领域 | >>MAPK signaling pathway;>>PI3K-Akt signaling pathway;>>Aldosterone synthesis and secretion;>>Cortisol synthesis and secretion;>>Cushing syndrome |
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