| 别名 | Interferon-inducible protein AIM2 |
| 基因名称 | Endogenous |
| 蛋白名称 | AIM2 |
| 推荐应用 | |
| 反应物种 | AIM2 |
| 存储缓冲液 | IHC 1:200-1:1000;WB 1:2000-1:10000;IF 1:200-1:1000;ELISA 1:5000-1:20000; |
| Human Gene Link | AIM2;Interferon-inducible protein AIM2;Absent in melanoma 2 |
| Human Swissprot No. | 9447 |
| Mouse Gene ID | O14862 |
| 特异性 | Monoclonal |
| 稀释度 | Unmodified |
| 参考分子量 | 39kD |
| 预测分子量 | WB,IHC,IF,ELISA |
| 运输及保存条件 | Protein A |
| 宿主 | 43kD |
| 同种型 | Rabbit |
| 背景介绍 | AIM2 is a member of the IFI20X /IFI16 family. It plays a putative role in tumorigenic reversion and may control cell proliferation. Interferon-gamma induces expression of AIM2. [provided by RefSeq, Jul 2008], |
| 细胞定位 | Nucleus. Cytoplasm. Activated inflammasomes can aggregate in the cytosol as speck-like particles. |
| 功能 | Disease:Defects in AIM2 may be a cause of microsatellite unstable colon cancers.,Function:Tumor suppressor which may act by repressing NF-kappa-B transcriptional activity.,induction:By interferon gamma.,similarity:Belongs to the HIN-200 family.,similarity:Contains 1 DAPIN domain.,similarity:Contains 1 HIN-200 domain.,subunit:Homodimer.,tissue specificity:Expressed in spleen, small intestine, peripheral blood leukocytes, and testis., |
| 纯化 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Clonality | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 修饰类型 | IgG,Kappa |
| 细胞定位 | Nucleus. Cytoplasm. Activated inflammasomes can aggregate in the cytosol as speck-like particles. |
| 组织表达 | Expressed in spleen, small intestine, peripheral blood leukocytes, and testis. |
| 研究领域 | >>NOD-like receptor signaling pathway;>>Cytosolic DNA-sensing pathway |
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