| 别名 | Polycomb complex protein BMI-1 |
| 基因名称 | Endogenous |
| 蛋白名称 | BMI1 |
| 推荐应用 | |
| 反应物种 | Bmi-1 |
| 存储缓冲液 | IHC 1:100-1:500;WB 1:2000-1:10000;IF 1:200-1:1000;ELISA 1:5000-1:20000;IP 1:50-1:200; |
| Human Gene Link | BMI1;PCGF4;RNF51;Polycomb complex protein BMI-1;Polycomb group RING finger protein 4;RING finger protein 51 |
| Human Swissprot No. | 648 |
| Mouse Gene ID | P35226 |
| 特异性 | Monoclonal |
| 稀释度 | Unmodified |
| 参考分子量 | 37kD |
| 预测分子量 | WB,IHC,IF,IP,ELISA |
| 运输及保存条件 | Protein A |
| 宿主 | 43kD |
| 同种型 | Rabbit |
| 背景介绍 | BMI1 proto-oncogene, polycomb ring finger(BMI1) Homo sapiens This gene encodes a ring finger protein that is major component of the polycomb group complex 1 (PRC1). This complex functions through chromatin remodeling as an essential epigenetic repressor of multiple regulatory genes involved in embryonic development and self-renewal in somatic stem cells. This protein also plays a central role in DNA damage repair. This gene is an oncogene and aberrant expression is associated with numerous cancers and is associated with resistance to certain chemotherapies. A pseudogene of this gene is found on chromosome X. Read-through transcription also exists between this gene and the upstream COMM domain containing 3 (COMMD3) gene. [provided by RefSeq, Sep 2015], |
| 细胞定位 | Nucleus . Cytoplasm . |
| 功能 | Disease:Cooperates with the MYC oncogene to produce B-lymphomas.,Function:Component of the Polycomb group (PcG) multiprotein PRC1 complex, a complex required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1 complex, it is required to stimulate the E3 ubiquitin-protein ligase activity of RNF2/RING2.,PTM:May be polyubiquitinated; which does not lead to proteasomal degradation.,similarity:Contains 1 RING-type zinc finger.,subunit:Component of chromatin-associated class II polycomb repressive complex 1 (PRC1/hPRC-H) at least composed of PCGF2/RNF110, BMI1/PCGF4, CBX2/M33, CBX4/PC2, CBX8/PC3, PHC1, PHC2, PHC3, SCMH1, RING1 and RNF2/RING2. Also component of E3 ubiquitin ligase complex or human polycomb repressive complex 1-like at least composed of PHC2, BMI1, RING1 and RNF2. Interacts with SPOP. Part of a complex consisting of BMI1, CUL3 and SPOP. Interacts with E4F1., |
| 纯化 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Clonality | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 修饰类型 | IgG,Kappa |
| 细胞定位 | Nucleus . Cytoplasm . |
| 组织表达 | Epithelium,Erythrocyte,Muscle,Thymus, |
| 研究领域 | >>Signaling pathways regulating pluripotency of stem cells;>>Transcriptional misregulation in cancer;>>MicroRNAs in cancer |
周一至周日 8:00-18:00
