| 别名 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform |
| 基因名称 | Endogenous |
| 蛋白名称 | PIK3CG |
| 推荐应用 | |
| 反应物种 | PI3-Kinase p110γ |
| 存储缓冲液 | WB 1:2000-1:10000;IF 1:200-1:1000;ELISA 1:5000-1:20000;IP 1:50-1:200; |
| Human Gene Link | PIK3CG;Phosphatidylinositol 4;5-bisphosphate 3-kinase catalytic subunit gamma isoform;PI3-kinase subunit gamma;PI3K-gamma;PI3Kgamma;PtdIns-3-kinase subunit gamma;Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit |
| Human Swissprot No. | 5294 |
| Mouse Gene ID | P48736 |
| 特异性 | Monoclonal |
| 稀释度 | Unmodified |
| 参考分子量 | 127kD |
| 预测分子量 | WB,IF,IP,ELISA |
| 运输及保存条件 | Protein A |
| 宿主 | 127kD |
| 同种型 | Rabbit |
| 背景介绍 | Phosphoinositide 3-kinases (PI3Ks) phosphorylate inositol lipids and are involved in the immune response. The protein encoded by this gene is a class I catalytic subunit of PI3K. Like other class I catalytic subunits (p110-alpha p110-beta, and p110-delta), the encoded protein binds a p85 regulatory subunit to form PI3K. This gene is located in a commonly deleted segment of chromosome 7 previously identified in myeloid leukemias. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jun 2015], |
| 细胞定位 | Cytoplasm . Cell membrane . |
| 功能 | Catalytic activity:ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate.,enzyme regulation:Activated by both the alpha and the beta-gamma G proteins.,Function:3-phosphorylates the cellular phosphoinositide PtdIns-4,5-biphosphate (PtdIns(4,5)P2) to produce PtdIns-3, 4,5-triiphosphate (PtdIns(3,4,5)P3). Links G-protein coupled receptor activation to the secondary messenger PtdIns(3,4,5)P3 production.,pathway:Phospholipid metabolism; phosphatidylinositol phosphate biosynthesis.,similarity:Belongs to the PI3/PI4-kinase family.,similarity:Contains 1 PI3K/PI4K domain.,subunit:Heterodimer of a catalytic subunit (PIK3CG/p120) and a regulatory (PIK3R5a/p101) subunit.,tissue specificity:Pancreas, skeletal muscle, liver and heart., |
| 纯化 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Clonality | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 修饰类型 | IgG,Kappa |
| 细胞定位 | Cytoplasm . Cell membrane . |
| 组织表达 | Pancreas, skeletal muscle, liver and heart. |
| 研究领域 | >>Inositol phosphate metabolism;>>Metabolic pathways;>>cGMP-PKG signaling pathway;>>Chemokine signaling pathway;>>Phospholipase D signaling pathway;>>PI3K-Akt signaling pathway;>>Adrenergic signaling in cardiomyocytes;>>Apelin signaling pathway;>>Platelet activation;>>Cholinergic synapse;>>Oxytocin signaling pathway;>>Salmonella infection;>>Toxoplasmosis;>>Kaposi sarcoma-associated herpesvirus infection |
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