| 别名 | Dual specificity mitogen-activated protein kinase kinase 7 |
| 基因名称 | Endogenous |
| 蛋白名称 | MAP2K7 |
| 推荐应用 | |
| 反应物种 | MKK7 |
| 存储缓冲液 | IHC 1:200-1:1000;WB 1:2000-1:10000;IF 1:200-1:1000;ELISA 1:5000-1:20000; |
| Human Gene Link | MAP2K7;JNKK2;MEK7;MKK7;PRKMK7;SKK4;Dual specificity mitogen-activated protein kinase kinase 7;MAP kinase kinase 7;MAPKK 7;JNK-activating kinase 2;MAPK/ERK kinase 7;MEK 7;Stress-activated protein kinase kinase 4;SAPK kinase 4;S |
| Human Swissprot No. | 5609 |
| Mouse Gene ID | O14733 |
| Mouse Swissprot No. | 26400 |
| Rat Gene ID | 363855 |
| Rat Swissprot No. | Q4KSH7 |
| 特异性 | Monoclonal |
| 稀释度 | Unmodified |
| 参考分子量 | 48kD |
| 预测分子量 | WB,IHC,IF,ELISA |
| 运输及保存条件 | Protein A |
| 宿主 | 48kD |
| 同种型 | Rabbit |
| 背景介绍 | The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically activates MAPK8/JNK1 and MAPK9/JNK2, and this kinase itself is phosphorylated and activated by MAP kinase kinase kinases including MAP3K1/MEKK1, MAP3K2/MEKK2,MAP3K3/MEKK5, and MAP4K2/GCK. This kinase is involved in the signal transduction mediating the cell responses to proinflammatory cytokines, and environmental stresses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014], |
| 细胞定位 | Nucleus. Cytoplasm . |
| 功能 | Catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,enzyme regulation:Activated by phosphorylation by specific MAP kinase kinase kinases such as MAP3K1/MEKK1, MAP3K3/MEKK3, MAP3K11/MLK3 and MAP3K12/DLK.,Function:Stress activated, dual specificity kinase that activates the JUN kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3.,PTM:Activated by phosphorylation on Ser/Thr.,similarity:Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.,similarity:Contains 1 protein kinase domain.,tissue specificity:Ubiquitous; with highest level of expression in skeletal muscle. Isoform 3 is found at low levels in placenta, fetal liver, and skeletal muscle., |
| 纯化 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Clonality | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 修饰类型 | IgG, Kappa |
| 细胞定位 | Nucleus. Cytoplasm . |
| 组织表达 | Ubiquitous; with highest level of expression in skeletal muscle. Isoform 3 is found at low levels in placenta, fetal liver, and skeletal muscle. |
| 研究领域 | >>MAPK signaling pathway;>>ErbB signaling pathway;>>Protein processing in endoplasmic reticulum;>>Osteoclast differentiation;>>Tight junction;>>Toll-like receptor signaling pathway;>>T cell receptor signaling pathway;>>Fc epsilon RI signaling pathway;>>TNF signaling pathway;>>Neurotrophin signaling pathway;>>GnRH signaling pathway;>>Relaxin signaling pathway;>>Alcoholic liver disease;>>Alzheimer disease;>>Huntington disease;>>Pathways of neurodegeneration - multiple diseases;>>Salmonella infection;>>Yersinia infection;>>Hepatitis B;>>Kaposi sarcoma-associated herpesvirus infection;>>Epstein-Barr virus infection;>>Human immunodeficiency virus 1 infection;>>Chemical carcinogenesis - reactive oxygen species;>>Lipid and atherosclerosis;>>Fluid shear stress and atherosclerosis |
周一至周日 8:00-18:00
