| 别名 | 5'-AMP-activated protein kinase subunit beta-1 |
| 基因名称 | Endogenous |
| 蛋白名称 | PRKAB1 |
| 推荐应用 | |
| 反应物种 | AMPKβ1 |
| 存储缓冲液 | IHC 1:100-1:500;WB 1:2000-1:10000;IF 1:200-1:1000;ELISA 1:5000-1:20000;IP 1:50-1:200; |
| Human Gene Link | PRKAB1;AMPK;5'-AMP-activated protein kinase subunit beta-1;AMPK subunit beta-1;AMPKb |
| Human Swissprot No. | 5564 |
| Mouse Gene ID | Q9Y478 |
| Mouse Swissprot No. | 19079 |
| Rat Gene ID | 83803 |
| Rat Swissprot No. | P80386 |
| 特异性 | Monoclonal |
| 稀释度 | Unmodified |
| 参考分子量 | 30kD |
| 预测分子量 | WB,IHC,IF,IP,ELISA |
| 运输及保存条件 | Protein A |
| 宿主 | 38kD |
| 同种型 | Rabbit |
| 背景介绍 | The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. The myristoylation and phosphorylation of this subunit have been shown to affect the enzyme activity and cellular localization of AMPK. This subunit may also serve as an adaptor molecule mediating the association of the AMPK complex. [provided |
| 细胞定位 | nucleus,nucleoplasm,cytosol,nucleotide-activated protein kinase complex, |
| 功能 | Function:AMPK is responsible for the regulation of fatty acid synthesis by phosphorylation of acetyl-CoA carboxylase. Also regulates cholesterol synthesis via phosphorylation and inactivation of hydroxymethylglutaryl-CoA reductase and hormone-sensitive lipase. This is a regulatory subunit, may be a positive regulator of AMPK activity. It may also serve as an adaptor molecule for the catalytic alpha-subunit.,PTM:Phosphorylated.,similarity:Belongs to the 5'-AMP-activated protein kinase beta subunit family.,subunit:Heterotrimer of an alpha catalytic subunit, a beta and a gamma non-catalytic regulatory subunits. Interacts with FNIP1 and FNIP2., |
| 纯化 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Clonality | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 修饰类型 | IgG,Kappa |
| 细胞定位 | nucleus,nucleoplasm,cytosol,nucleotide-activated protein kinase complex, |
| 组织表达 | Brain,Lung,Muscle,Platelet, |
| 研究领域 | >>FoxO signaling pathway;>>AMPK signaling pathway;>>Longevity regulating pathway;>>Longevity regulating pathway - multiple species;>>Apelin signaling pathway;>>Tight junction;>>Circadian rhythm;>>Thermogenesis;>>Insulin signaling pathway;>>Adipocytokine signaling pathway;>>Oxytocin signaling pathway;>>Glucagon signaling pathway;>>Insulin resistance;>>Non-alcoholic fatty liver disease;>>Alcoholic liver disease;>>Hypertrophic cardiomyopathy |
周一至周日 8:00-18:00
