| 别名 | Protein kinase C and casein kinase substrate in neurons protein 3;SH3 domain-containing protein 6511; |
| 基因名称 | Endogenous |
| 蛋白名称 | PACSIN3 |
| 推荐应用 | |
| 反应物种 | PACSIN3 |
| 存储缓冲液 | WB 1:1000-5000;IHC 1:100-300;ICC/IF 1:100-300;FC 1:100-300;IP 1:50-100 |
| Human Gene Link | PACSIN3;Protein kinase C and casein kinase substrate in neurons protein 3 ;SH3 domain-containing protein 6511; |
| Human Swissprot No. | 29763 |
| Mouse Gene ID | Q9UKS6 |
| Mouse Swissprot No. | 80708 |
| 特异性 | Monoclonal |
| 稀释度 | Unmodified |
| 预测分子量 | WB,IHC,IF,ICC,FC,IP |
| 运输及保存条件 | Protein A |
| 宿主 | 47kD |
| 同种型 | Rabbit |
| 背景介绍 | This gene is a member of the protein kinase C and casein kinase substrate in neurons family. The encoded protein is involved in linking the actin cytoskeleton with vesicle formation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010] |
| 细胞定位 | Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Detected at the inner aspect of the plasma membrane in myotubes.. |
| 功能 | Plays a role in endocytosis and regulates internalization of plasma membrane proteins. Overexpression impairs internalization of SLC2A1/GLUT1 and TRPV4 and increases the levels of SLC2A1/GLUT1 and TRPV4 at the cell membrane. Inhibits the TRPV4 calcium channel activity (By similarity). {ECO:0000250, ECO:0000269|PubMed:11082044}. |
| 纯化 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Clonality | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 修饰类型 | IgG,Kappa |
| 细胞定位 | Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Detected at the inner aspect of the plasma membrane in myotubes.. |
| 组织表达 | Widely expressed, with highest levels in heart and skeletal muscle, intermediate levels in placenta, liver and pancreas, and very low levels in brain, lung and kidney. {ECO:0000269|PubMed:11082044, ECO:0000269|PubMed:11179684}. |
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