| 别名 | Cystathionine gamma-lyase (Cysteine-protein sulfhydrase) (Gamma-cystathionase) |
| 基因名称 | Endogenous |
| 蛋白名称 | CTH |
| 推荐应用 | |
| 反应物种 | Cystathionase |
| 存储缓冲液 | IHC 1:200-1:1000;WB 1:2000-1:10000;IF 1:200-1:1000;ELISA 1:5000-1:20000;IP 1:50-1:200; |
| Human Swissprot No. | 1491 |
| Mouse Gene ID | P32929 |
| Rat Swissprot No. | P18757 |
| 特异性 | Monoclonal |
| 稀释度 | Unmodified |
| 参考分子量 | 45kD |
| 预测分子量 | WB,IHC,IF,IP,ELISA |
| 运输及保存条件 | Protein A |
| 宿主 | 45kD |
| 同种型 | Rabbit |
| 背景介绍 | This gene encodes a cytoplasmic enzyme in the trans-sulfuration pathway that converts cystathione derived from methionine into cysteine. Glutathione synthesis in the liver is dependent upon the availability of cysteine. Mutations in this gene cause cystathioninuria. Alternative splicing of this gene results in three transcript variants encoding different isoforms. [provided by RefSeq, Jun 2010], |
| 细胞定位 | Cytoplasm. |
| 功能 | Catalytic activity:L-cystathionine + H(2)O = L-cysteine + NH(3) + 2-oxobutanoate.,cofactor:Pyridoxal phosphate.,Disease:Defects in CTH are the cause of cystathioninuria [MIM:219500]. CTH is an autosomal recessive phenotype characterized by abnormal accumulation of plasma cystathionine, leading to increased urinary excretion.,pathway:Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-homocysteine and L-serine: step 2/2.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the trans-sulfuration enzymes family.,subunit:Homotetramer., |
| 纯化 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Clonality | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 修饰类型 | IgG, Kappa |
| 细胞定位 | Cytoplasm. |
| 组织表达 | Highly expressed in liver (PubMed:10727430, PubMed:20305127). Also in muscle and lower expression in most tissues except heart, pituitary gland, spleen, thymus, and vascular tissue, where it is hardly detected (PubMed:20305127). |
| 研究领域 | >>Glycine, serine and threonine metabolism;>>Cysteine and methionine metabolism;>>Selenocompound metabolism;>>Metabolic pathways;>>Biosynthesis of amino acids |
周一至周日 8:00-18:00
