| 别名 | Eukaryotic translation initiation factor 2-alpha kinase 4 |
| 基因名称 | Endogenous |
| 蛋白名称 | EIF2AK4 |
| 推荐应用 | |
| 反应物种 | GCN2 |
| 存储缓冲液 | IHC 1:100-1:500;WB 1:2000-1:10000;IF 1:200-1:1000;ELISA 1:5000-1:20000; |
| Human Gene Link | EIF2AK4;GCN2;KIAA1338;Eukaryotic translation initiation factor 2-alpha kinase 4;GCN2-like protein |
| Human Swissprot No. | 440275 |
| Mouse Gene ID | Q9P2K8 |
| Mouse Swissprot No. | 27103 |
| 特异性 | Monoclonal |
| 稀释度 | Unmodified |
| 参考分子量 | 187kD |
| 预测分子量 | WB,IHC,IF,ELISA |
| 运输及保存条件 | Protein A |
| 宿主 | 187kD |
| 同种型 | Rabbit |
| 背景介绍 | This gene encodes a member of a family of kinases that phosphorylate the alpha subunit of eukaryotic translation initiation factor-2 (EIF2), resulting in the downregulaton of protein synthesis. The encoded protein responds to amino acid deprivation by binding uncharged transfer RNAs. It may also be activated by glucose deprivation and viral infection. Mutations in this gene have been found in individuals suffering from autosomal recessive pulmonary venoocclusive-disease-2. [provided by RefSeq, Mar 2014], |
| 细胞定位 | Cytoplasm . |
| 功能 | Catalytic activity:ATP + a protein = ADP + a phosphoprotein.,Domain:Kinase domain 1 is a degenerate kinase domain.,Domain:RWD domain is reported to interact with GCN1L1.,Function:Can phosphorylate the alpha subunit of EIF2 and may mediate translational control.,PTM:Autophosphorylated on threonine residues.,similarity:Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.,similarity:Contains 1 RWD domain.,similarity:Contains 2 protein kinase domains.,tissue specificity:Widely expressed., |
| 纯化 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Clonality | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 修饰类型 | IgG, Kappa |
| 细胞定位 | Cytoplasm . |
| 组织表达 | Widely expressed (PubMed:10504407). Expressed in lung, smooth muscle cells and macrophages (PubMed:24292273). |
| 研究领域 | >>Autophagy - animal;>>Protein processing in endoplasmic reticulum;>>Hepatitis C;>>Measles;>>Herpes simplex virus 1 infection |
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