| 别名 | Glutathione peroxidase 1 (GPx-1) (GSHPx-1) (Cellular glutathione peroxidase) |
| 基因名称 | Endogenous |
| 蛋白名称 | GPX1 |
| 推荐应用 | |
| 反应物种 | GPX1 |
| 存储缓冲液 | IHC 1:200-1:1000;WB 1:2000-1:10000;IF 1:200-1:1000;ELISA 1:5000-1:20000;IP 1:50-1:200; |
| Human Swissprot No. | 2876 |
| Mouse Gene ID | P07203 |
| Rat Swissprot No. | P04041 |
| 特异性 | Monoclonal |
| 稀释度 | Unmodified |
| 参考分子量 | 22kD |
| 预测分子量 | WB,IHC,IF,IP,ELISA |
| 运输及保存条件 | Protein A |
| 宿主 | 22kD |
| 同种型 | Rabbit |
| 背景介绍 | The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of organic hydroperoxides and hydrogen peroxide (H2O2) by glutathione, and thereby protect cells against oxidative damage. Other studies indicate that H2O2 is also essential for growth-factor mediated signal transduction, mitochondrial function, and maintenance of thiol redox-balance; therefore, by limiting H2O2 accumulation, glutathione peroxidases are also involved in modulating these processes. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme is the most abundant, is ubiquitously expressed and localized in the cytoplasm, and whose preferred substrate is hydrogen peroxide. It is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA cod |
| 细胞定位 | Cytoplasm. |
| 功能 | Catalytic activity:2 glutathione + H(2)O(2) = glutathione disulfide + 2 H(2)O.,Function:Protects the hemoglobin in erythrocytes from oxidative breakdown.,online information:Glutathione peroxidase entry,similarity:Belongs to the glutathione peroxidase family.,subunit:Homotetramer., |
| 纯化 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Clonality | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 修饰类型 | IgG,Kappa |
| 细胞定位 | Cytoplasm. |
| 组织表达 | Expressed in platelets (at protein level). |
| 研究领域 | >>Glutathione metabolism;>>Arachidonic acid metabolism;>>Metabolic pathways;>>Thyroid hormone synthesis;>>Amyotrophic lateral sclerosis;>>Huntington disease;>>Pathways of neurodegeneration - multiple diseases |
周一至周日 8:00-18:00
