| 别名 | Germinal center-associated signaling and motility protein;Germinal center B-cell-expressed transcript 2 protein;Germinal center-associated lymphoma protein;hGAL; |
| 基因名称 | Endogenous |
| 蛋白名称 | GCSAM;GAL;GCET2 |
| 推荐应用 | |
| 反应物种 | GCSAM |
| 存储缓冲液 | IHC 1:100-300;ICC/IF 1:100-300;FC 1:100-300 |
| Human Gene Link | GCSAM;GAL;GCET2;Germinal center-associated signaling and motility protein ;Germinal center B-cell-expressed transcript 2 protein;Germinal center-associated lymphoma protein;hGAL; |
| Human Swissprot No. | 257144 |
| Mouse Gene ID | Q8N6F7 |
| Mouse Swissprot No. | 14525 |
| 特异性 | Monoclonal |
| 稀释度 | Unmodified |
| 预测分子量 | IHC,IF,ICC,FC |
| 运输及保存条件 | Protein A |
| 宿主 | 20kD |
| 同种型 | Rabbit |
| 背景介绍 | This gene encodes a protein which may function in signal transduction pathways and whose expression is elevated in germinal cell lymphomas. It contains a putative PDZ-interacting domain, an immunoreceptor tyrosine-based activation motif (ITAM), and two putative SH2 binding sites. In B cells, its expression is specifically induced by interleukin-4. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] |
| 细胞定位 | Cytoplasm. Cell membrane. Note=It relocalizes from the cytoplasm to podosome-like structures upon cell treatment with IL6. |
| 功能 | Involved in the negative regulation of lymphocyte motility. It mediates the migration-inhibitory effects of IL6. Serves as a positive regulator of the RhoA signaling pathway. Enhancement of RhoA activation results in inhibition of lymphocyte and lymphoma cell motility by activation of its downstream effector ROCK. Is a regulator of B-cell receptor signaling, that acts through SYK kinase activation. {ECO:0000269|PubMed:17823310, ECO:0000269|PubMed:20844236, ECO:0000269|PubMed:23299888}. |
| 纯化 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Clonality | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 修饰类型 | IgG,Kappa |
| 细胞定位 | Cytoplasm. Cell membrane. Note=It relocalizes from the cytoplasm to podosome-like structures upon cell treatment with IL6. |
| 组织表达 | Expressed in diffuse large B-cell lymphoma (DLBCL) and several germinal center (GC)-like lymphoma cell lines (at protein level). Highly expressed in normal GC lymphocytes and GC-derived malignancies. Expressed in thymus and spleen. {ECO:0000269|PubMed:12509382, ECO:0000269|PubMed:12819018, ECO:0000269|PubMed:15677569}. |
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