| 别名 | Ribosomal protein S6 kinase beta-2 |
| 基因名称 | Phospho-p70 S6 kinase β (S371) Antibody detects endogenous levels of p70 S6 kinase β protein only when phosphorylated at S371.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):DSpDD |
| 蛋白名称 | RPS6KB2 |
| 推荐应用 | |
| 反应物种 | P70S6k |
| 存储缓冲液 | IHC 1:500-1:2000;WB 1:2000-1:10000;IF 1:200-1:1000;ELISA 1:5000-1:20000; |
| Human Gene Link | RPS6KB2;STK14B;Ribosomal protein S6 kinase beta-2;S6K-beta-2;S6K2;70 kDa ribosomal protein S6 kinase 2;P70S6K2;p70-S6K 2;S6 kinase-related kinase;SRK;Serine/threonine-protein kinase 14B;p70 ribosomal S6 kinase beta;S6K-beta;p70 |
| Human Swissprot No. | 6199 |
| Mouse Gene ID | Q9UBS0 |
| Mouse Swissprot No. | 58988 |
| 特异性 | Monoclonal |
| 稀释度 | Phospho |
| 参考分子量 | 53kD |
| 预测分子量 | WB,IHC,IF,ELISA |
| 运输及保存条件 | Protein A |
| 宿主 | 60kD |
| 同种型 | Rabbit |
| 背景介绍 | ribosomal protein S6 kinase B2(RPS6KB2) Homo sapiens This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains a kinase catalytic domain and phosphorylates the S6 ribosomal protein and eukaryotic translation initiation factor 4B (eIF4B). Phosphorylation of S6 leads to an increase in protein synthesis and cell proliferation. [provided by RefSeq, Jan 2015], |
| 细胞定位 | Cytoplasm. Nucleus. |
| 功能 | Catalytic activity:ATP + a protein = ADP + a phosphoprotein.,Function:Phosphorylates specifically ribosomal protein S6.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.,similarity:Contains 1 AGC-kinase C-terminal domain.,similarity:Contains 1 protein kinase domain., |
| 纯化 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Clonality | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 修饰类型 | IgG,Kappa |
| 细胞定位 | Cytoplasm. Nucleus. |
| 组织表达 | Brain,Epithelium,Lymph, |
| 研究领域 | >>EGFR tyrosine kinase inhibitor resistance;>>Endocrine resistance;>>ErbB signaling pathway;>>HIF-1 signaling pathway;>>Autophagy - animal;>>mTOR signaling pathway;>>PI3K-Akt signaling pathway;>>AMPK signaling pathway;>>Longevity regulating pathway;>>Longevity regulating pathway - multiple species;>>TGF-beta signaling pathway;>>Apelin signaling pathway;>>Fc gamma R-mediated phagocytosis;>>Thermogenesis;>>Insulin signaling pathway;>>Insulin resistance;>>Shigellosis;>>Human cytomegalovirus infection;>>Human papillomavirus infection;>>Human immunodeficiency virus 1 infection;>>Pathways in cancer;>>Proteoglycans in cancer;>>Chemical carcinogenesis - receptor activation;>>Colorectal cancer;>>Pancreatic cancer;>>Acute myeloid leukemia;>>Breast cancer;>>Hepatocellular carcinoma;>>Gastric cancer;>>Choline metabolism in cancer;>>PD-L1 expression and PD-1 checkpoint pathway in cancer |
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