| 别名 | Tenascin |
| 基因名称 | Endogenous |
| 蛋白名称 | TNC |
| 推荐应用 | |
| 反应物种 | Tenascin-C |
| 存储缓冲液 | IHC 1:500-1:2000;WB 1:2000-1:10000;IF 1:200-1:1000;ELISA 1:5000-1:20000; |
| Human Gene Link | TNC;HXB;Tenascin;TN;Cytotactin;GMEM;GP 150-225;Glioma-associated-extracellular matrix antigen;Hexabrachion;JI;Myotendinous antigen;Neuronectin;Tenascin-C;TN-C |
| Human Swissprot No. | 3371 |
| Mouse Gene ID | P24821 |
| Mouse Swissprot No. | 21923 |
| 特异性 | Monoclonal |
| 稀释度 | Unmodified |
| 参考分子量 | 241kD |
| 预测分子量 | WB,IHC,IF,ELISA |
| 运输及保存条件 | Protein A |
| 宿主 | 270kD |
| 同种型 | Rabbit |
| 背景介绍 | tenascin C(TNC) Homo sapiens This gene encodes an extracellular matrix protein with a spatially and temporally restricted tissue distribution. This protein is homohexameric with disulfide-linked subunits, and contains multiple EGF-like and fibronectin type-III domains. It is implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity, and neuronal regeneration. [provided by RefSeq, Jul 2011], |
| 细胞定位 | Secreted, extracellular space, extracellular matrix. |
| 功能 | Alternative products:Isoforms are produced in a tissue- and time-specific manner during development,Function:Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth from cortical neurons grown on a monolayer of astrocytes. Ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-V/beta-3 and alpha-V/beta-6.,induction:By TGF-beta.,PTM:N-glycosylated.,similarity:Belongs to the tenascin family.,similarity:Contains 1 fibrinogen C-terminal domain.,similarity:Contains 15 EGF-like domains.,similarity:Contains 15 fibronectin type-III domains.,subunit:Homohexamer; disulfide-linked. A homotrimer may be formed in the triple coiled-coil region and may be stabilized by disulfide rings at both ends. Two of such half-hexabrachions may be disulfide linked within the central globule. Interacts with CSPG4., |
| 纯化 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Clonality | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 修饰类型 | IgG,Kappa |
| 细胞定位 | Secreted, extracellular space, extracellular matrix. |
| 组织表达 | Brain,Fetal brain,Fetal cartilage,Glioblastoma,Human fetal kidney,Liver,Melanoma,Milk,Plasma, |
| 研究领域 | >>PI3K-Akt signaling pathway;>>Focal adhesion;>>ECM-receptor interaction;>>Human papillomavirus infection;>>MicroRNAs in cancer |
周一至周日 8:00-18:00
