| 别名 | Acyl-CoA desaturase (Delta(9)-desaturase) (Delta-9 desaturase) (Fatty acid desaturase) (Stearoyl-CoA desaturase) |
| 基因名称 | Endogenous |
| 蛋白名称 | SCD |
| 推荐应用 | |
| 反应物种 | SCD |
| 存储缓冲液 | IHC 1:200-1:1000;WB 1:2000-1:10000;IF 1:200-1:1000;ELISA 1:5000-1:20000; |
| Human Swissprot No. | 6319 |
| Mouse Gene ID | O00767 |
| 特异性 | Monoclonal |
| 稀释度 | Unmodified |
| 参考分子量 | 42kD |
| 预测分子量 | WB,IHC,IF,ELISA |
| 运输及保存条件 | Protein A |
| 宿主 | 37kD |
| 同种型 | Rabbit |
| 背景介绍 | This gene encodes an enzyme involved in fatty acid biosynthesis, primarily the synthesis of oleic acid. The protein belongs to the fatty acid desaturase family and is an integral membrane protein located in the endoplasmic reticulum. Transcripts of approximately 3.9 and 5.2 kb, differing only by alternative polyadenlyation signals, have been detected. A gene encoding a similar enzyme is located on chromosome 4 and a pseudogene of this gene is located on chromosome 17. [provided by RefSeq, Sep 2015], |
| 细胞定位 | Endoplasmic reticulum membrane ; Multi-pass membrane protein . |
| 功能 | Catalytic activity:Stearoyl-CoA + 2 ferrocytochrome b5 + O(2) + 2 H(+) = oleoyl-CoA + 2 ferricytochrome b5 + 2 H(2)O.,cofactor:Iron.,Domain:The histidine box domains may contain the active site and/or be involved in metal ion binding.,Function:Terminal component of the liver microsomal stearyl-CoA desaturase system, that utilizes O(2) and electrons from reduced cytochrome b5 to catalyze the insertion of a double bond into a spectrum of fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA.,similarity:Belongs to the fatty acid desaturase family., |
| 纯化 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Clonality | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 修饰类型 | IgG,Kappa |
| 细胞定位 | Endoplasmic reticulum membrane ; Multi-pass membrane protein . |
| 组织表达 | Detected in fetal liver, lung and brain. Highly expressed in adult adipose tissue, and at lower levels in adult brain and lung. |
| 研究领域 | >>Biosynthesis of unsaturated fatty acids;>>Metabolic pathways;>>Fatty acid metabolism;>>PPAR signaling pathway;>>AMPK signaling pathway;>>Alcoholic liver disease |
周一至周日 8:00-18:00
