| 别名 | Transcription factor HES-1 (Class B basic helix-loop-helix protein 39) (bHLHb39) (Hairy and enhancer of split 1) (Hairy homolog) (Hairy-like protein) (hHL) |
| 基因名称 | Endogenous |
| 蛋白名称 | HES1 BHLHB39 HL HRY |
| 推荐应用 | |
| 反应物种 | HES1 |
| 存储缓冲液 | IHC 1:4000-1:20000;WB 1:2000-1:10000;IF 1:200-1:1000;ELISA 1:5000-1:20000; |
| Human Swissprot No. | 3280 |
| Mouse Gene ID | Q14469 |
| Rat Swissprot No. | Q04666 |
| 特异性 | Monoclonal |
| 稀释度 | Unmodified |
| 参考分子量 | 30kD |
| 预测分子量 | WB,IHC,IF,ELISA |
| 运输及保存条件 | Protein A |
| 宿主 | 30kD |
| 同种型 | Rabbit |
| 背景介绍 | This protein belongs to the basic helix-loop-helix family of transcription factors. It is a transcriptional repressor of genes that require a bHLH protein for their transcription. The protein has a particular type of basic domain that contains a helix interrupting protein that binds to the N-box rather than the canonical E-box. [provided by RefSeq, Jul 2008], |
| 细胞定位 | Nucleus. |
| 功能 | Domain:Has a particular type of basic domain (presence of a helix-interrupting proline) that binds to the N-box (CACNAG), rather than the canonical E-box (CANNTG).,Domain:The bHLH, as well as cooperation between the central Orange domain and the C-terminal WRPW motif, is required for transcriptional repressor activity.,Domain:The C-terminal WRPW motif is a transcriptional repression domain necessary for the interaction with Groucho/TLE family members, transcriptional corepressors recruited to specific target DNA by Hairy-related proteins.,Function:Transcriptional repressor of genes that require a bHLH protein for their transcription. May act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1. Binds DNA on N-box motifs: 5'-CACNAG-3' with high affinity and on E-box motifs: 5'-CANNTG-3' with low affinity.,similarity:Contains 1 basic helix-loop-helix (bHLH) domain.,similarity:Contains 1 Orange domain.,subunit:Transcription repression requires formation of a complex with a corepressor protein of the Groucho/TLE family. Interacts (via WPRW motif) with TLE1, and more weakly with TLE2. Interacts with HES6 (By similarity). Interacts with SIRT1., |
| 纯化 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Clonality | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 修饰类型 | IgG,Kappa |
| 细胞定位 | Nucleus. |
| 组织表达 | Kidney,Prostate,Skin, |
| 研究领域 | >>Fanconi anemia pathway;>>Notch signaling pathway;>>Maturity onset diabetes of the young;>>Human papillomavirus infection;>>Epstein-Barr virus infection;>>Pathways in cancer;>>Breast cancer |
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