| 别名 | Myeloperoxidase(MPO) |
| 基因名称 | Endogenous |
| 蛋白名称 | MPO |
| 推荐应用 | |
| 反应物种 | MPO |
| 存储缓冲液 | IHC 1:500-1:1000;WB 1:2000-1:10000;IF 1:200-1:1000;ELISA 1:5000-1:20000; |
| Human Swissprot No. | 4353 |
| Mouse Gene ID | P05164 |
| 特异性 | Monoclonal |
| 稀释度 | Unmodified |
| 参考分子量 | 84kD |
| 预测分子量 | WB,IHC,IF,ELISA |
| 运输及保存条件 | Protein A |
| 宿主 | 60,80-90kD |
| 同种型 | Rabbit |
| 背景介绍 | Myeloperoxidase (MPO) is a heme protein synthesized during myeloid differentiation that constitutes the major component of neutrophil azurophilic granules. Produced as a single chain precursor, myeloperoxidase is subsequently cleaved into a light and heavy chain. The mature myeloperoxidase is a tetramer composed of 2 light chains and 2 heavy chains. This enzyme produces hypohalous acids central to the microbicidal activity of neutrophils. [provided by RefSeq, Nov 2014] |
| 细胞定位 | Cytoplasmic |
| 功能 | Catalytic activity:Cl(-) + H(2)O(2) = HOCl + 2 H(2)O.,Catalytic activity:Donor + H(2)O(2) = oxidized donor + 2 H(2)O.,cofactor:Binds 1 calcium ion per heterodimer.,cofactor:Binds 1 heme B (iron-protoporphyrin IX) group covalently per heterodimer.,Disease:Defects in MPO are the cause of myeloperoxidase deficiency (MPD) [MIM:254600]. MPD is an autosomal recessive defect that results in disseminated candidiasis.,Function:Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity.,online information:MPO mutation db,online information:Myeloperoxidase entry,similarity:Belongs to the peroxidase family. XPO subfamily.,subunit:Tetramer of two light chains and two heavy chains., |
| 纯化 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Clonality | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 修饰类型 | IgG,Kappa |
| 细胞定位 | Cytoplasmic |
| 组织表达 | Leukemia,Leukocyte,Liver,Plasma,Saliva, |
| 研究领域 | >>Drug metabolism - other enzymes;>>Phagosome;>>Neutrophil extracellular trap formation;>>Transcriptional misregulation in cancer;>>Acute myeloid leukemia |
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