| 别名 | MFN1 |
| 基因名称 | Endogenous |
| 蛋白名称 | MFN1 |
| 推荐应用 | |
| 反应物种 | MFN1 |
| 存储缓冲液 | WB 1:2000-1:10000;IF 1:200-1:1000;ELISA 1:5000-1:20000;IP 1:50-1:200; |
| Human Gene Link | Mitofusin-1;Fzo homolog;Transmembrane GTPase MFN1; |
| Human Swissprot No. | 55669 |
| Mouse Gene ID | Q8IWA4 |
| Mouse Swissprot No. | 67414 |
| Rat Gene ID | 192647 |
| Rat Swissprot No. | Q8R4Z9 |
| 特异性 | Monoclonal |
| 稀释度 | Unmodified |
| 参考分子量 | 84kD |
| 预测分子量 | WB,IF,IP,ELISA |
| 运输及保存条件 | Protein A |
| 宿主 | 84kD |
| 同种型 | Rabbit |
| 背景介绍 | The protein encoded by this gene is a mediator of mitochondrial fusion. This protein and mitofusin 2 are homologs of the Drosophila protein fuzzy onion (Fzo). They are mitochondrial membrane proteins that interact with each other to facilitate mitochondrial targeting. [provided by RefSeq, Jul 2008], |
| 细胞定位 | Mitochondrion outer membrane ; Multi-pass membrane protein .; [Isoform 2]: Cytoplasm . |
| 功能 | Catalytic activity:GTP + H(2)O = GDP + phosphate.,Function:Essential transmembrane GTPase, which mediates mitochondrial fusion. Fusion of mitochondria occurs in many cell types and constitutes an important step in mitochondria morphology, which is balanced between fusion and fission. MFN1 acts independently of the cytoskeleton. Overexpression induces the formation of mitochondrial networks.,similarity:Belongs to the mitofusin family.,subunit:Forms homomultimers and heteromultimers with MFN2. Multimerization, which is probably mediated by the coiled coil region, may play an essential role in mitochondrion fusion (By similarity). Participates in a high molecular weight multiprotein complex.,tissue specificity:Ubiquitous. Expressed at slightly higher level in kidney and heart. Isoform 2 may be overexpressed in some tumors, such as lung cancers., |
| 纯化 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Clonality | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 修饰类型 | IgG,Kappa |
| 细胞定位 | Mitochondrion outer membrane ; Multi-pass membrane protein .; [Isoform 2]: Cytoplasm . |
| 组织表达 | Detected in kidney and heart (at protein level) (PubMed:12759376). Ubiquitous (PubMed:11950885, PubMed:12759376). Expressed at slightly higher level in kidney and heart (PubMed:12759376). Isoform 2 may be overexpressed in some tumors, such as lung cancers (PubMed:11751411). |
| 研究领域 | >>Mitophagy - animal;>>NOD-like receptor signaling pathway;>>Parkinson disease;>>Pathways of neurodegeneration - multiple diseases |
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